Compile Data Set for Download or QSAR
Report error Found 146 Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [M918T]'
LigandPNGBDBM576988(US11472802, Example 8)
Affinity DataIC50: 0.0170nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577053(US11472802, Example 58)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM716172(US12209085, Example 215)
Affinity DataIC50: 0.183nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
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LigandPNGBDBM577046(7-chloro-3-(5-cyclopropyl- 4-(1H-pyrazol-3- yl)iso...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577049(US11472802, Example 55)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577050(7-chloro-3-(5- cyclopropyl-4-(1H- imidazol-4- yl)i...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577063(1-(3-(4-amino-7-chloro-1- isopropyl-1H-pyrazolo[4,...)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM576996(US11472802, Example 11)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577025(7-chloro-3-(5-cyclopropyl-4- (pyrazin-2-yl)isoxazo...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577026(7-chloro-3-(5-cyclopropyl-4-(4- methylpyridin-2-yl...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577045(US11472802, Example 51)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577061(US11472802, Example 65)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577064(US11472802, Example 68)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577066(3-(5-cyclopropyl- 4-(1H-pyrazol-3- yl)isoxazol-3- ...)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM597662(US11603374, Example 17)
Affinity DataIC50: 0.300nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM716174(US12209085, Example 214)
Affinity DataIC50: 0.300nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
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LigandPNGBDBM577029(7-chloro-3-(5-cyclopropyl-4-(5- methylpyridin-2-yl...)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577062(1-(3-(4-amino-7-chloro-1- isopropyl-1H-pyrazolo[4,...)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM597647(US11603374, Example 2)
Affinity DataIC50: 0.400nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM577047(7-chloro-3-(5-cyclopropyl- 4-(1-methyl-1H-pyrazol-...)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577067(3-(5-cyclopropyl- 4-(5-methyl-1H- pyrazol-3-yl) is...)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM597646(US11603374, Example 1)
Affinity DataIC50: 0.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM597673(US11603374, Example 28)
Affinity DataIC50: 0.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM597674(US11603374, Example 29)
Affinity DataIC50: 0.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM577032(US11472802, Example 39)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM597672((3-(4-amino-5-(5- cyclopropylisoxazol-3-yl)- 7H-py...)
Affinity DataIC50: 0.600nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM716173(US12209085, Example 194)
Affinity DataIC50: 0.620nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
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LigandPNGBDBM576985(US11472802, Example 6)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577048(7-chloro-3-(5-cyclopropyl- 4-(1-ethyl-1H-pyrazol-3...)
Affinity DataIC50: 0.700nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM597663(7-cyclobutyl-5-(5- cyclopropylisoxazol-3-yl)- 7H-p...)
Affinity DataIC50: 0.700nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM597675(US11603374, Example 30)
Affinity DataIC50: 0.700nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM716170(US12209085, Example 3)
Affinity DataIC50: 0.700nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
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LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 0.75nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM577015(3-(5-cyclopropyl-4-(4- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577022(3-(5-cyclopropyl-4-(1-methyl- 1H-imidazol-4-yl)iso...)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577028(7-chloro-3-(5-cyclopropyl-4-(6- methylpyridin-2-yl...)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM597648(US11603374, Example 3)
Affinity DataIC50: 0.800nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM597669(5-(5-cyclopropylisoxazol-3- yl)-7-(1,1,1-trifluoro...)
Affinity DataIC50: 0.800nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM625352(US20230322769, Compound 65)
Affinity DataIC50: 0.920nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM716112(US12209085, Example 1)
Affinity DataIC50: 0.970nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
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LigandPNGBDBM577065(US11472802, Example 69)
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM597668(2-(4-amino-5-(5- cyclopropylisoxazol-3-yl)- 7H-pyr...)
Affinity DataIC50: 1nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM577006(US11472802, Example 17)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577019(3-(5-cyclopropyl-4-(5- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM577008(US11472802, Example 19)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
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LigandPNGBDBM597665(US11603374, Example 20)
Affinity DataIC50: 1.30nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM597649(US11603374, Example 4)
Affinity DataIC50: 1.40nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM597676(US11603374, Example 31)
Affinity DataIC50: 1.40nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2023
Entry Details
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LigandPNGBDBM625338(US20230322769, Compound 20)
Affinity DataIC50: 1.45nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625369(US20230322769, Compound 89)
Affinity DataIC50: 1.47nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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