Compile Data Set for Download or QSAR
Report error Found 214 Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 6'
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataKd:  6nMpH: 8.5Assay Description:Isothermal titration calorimetry (ITC) was performed at 25 °C in a Nano ITC instrument (TA Instruments, USA). The cell was loaded with 25 μM PRM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50158094(CHEMBL3780926)
Affinity DataKd:  970nMAssay Description:Binding affinity to Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataKd:  87nMAssay Description:Binding affinity to human PRMT6 in presence of SAH by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50243294(CHEMBL4094513)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PRMT6 (unknown origin) incubated for 15 mins followed by substrate addition measured after 60 mins by AlphaLisa methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2019
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095436(CHEMBL3589043)
Affinity DataIC50: 2nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095355(CHEMBL3589029)
Affinity DataIC50: 2nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095438(CHEMBL3589042)
Affinity DataIC50: 3nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human PRMT6 assessed as inhibition of methylation activity using biotin-labeled peptide as substrate and [3H]-SAM by scintillation prox...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PRMT6 (unknown origin) using biotinylated histone H4 (1 to 24 residues) as substrate in presence of [3H]SAM by scintillation proximity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of PRMT6 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM178103(MS023 (Compound 3) | N1-((4-(4-isopropoxyphenyl)-1...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human PRMT6 using S-adenosyl-L-methionine (3H) as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095435(CHEMBL3590417)
Affinity DataIC50: 5nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095432(CHEMBL3589026)
Affinity DataIC50: 7nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095441(CHEMBL3589039)
Affinity DataIC50: 7.10nMAssay Description:Inhibition of PRMT6 (unknown origin) by AlphaLISA assay in vitro assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095354(CHEMBL3589030)
Affinity DataIC50: 8nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095441(CHEMBL3589039)
Affinity DataIC50: 10nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095353(CHEMBL3589031)
Affinity DataIC50: 10nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095356(CHEMBL3589028)
Affinity DataIC50: 10nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095357(CHEMBL3589027)
Affinity DataIC50: 11nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095434(CHEMBL3589912)
Affinity DataIC50: 11nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095440(CHEMBL3589040)
Affinity DataIC50: 13nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50511923(CHEMBL4463793)
Affinity DataIC50: 18nMAssay Description:Inhibition of human PRMT6 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50511923(CHEMBL4463793)
Affinity DataIC50: 18nMAssay Description:Inhibition of human PRMT6 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095439(CHEMBL3589041)
Affinity DataIC50: 20nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095352(CHEMBL3589032)
Affinity DataIC50: 23nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095351(CHEMBL3589033)
Affinity DataIC50: 25nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095433(CHEMBL3589913)
Affinity DataIC50: 25nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194730(CHEMBL3906680)
Affinity DataIC50: 25nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194785(CHEMBL3956007)
Affinity DataIC50: 25nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194728(CHEMBL3984626)
Affinity DataIC50: 26nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194763(CHEMBL3957029)
Affinity DataIC50: 27nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194773(CHEMBL3939593)
Affinity DataIC50: 28nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50511921(CHEMBL4544587)
Affinity DataIC50: 28nMAssay Description:Inhibition of human PRMT6 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50511921(CHEMBL4544587)
Affinity DataIC50: 28nMAssay Description:Inhibition of human PRMT6 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194758(CHEMBL3970878)
Affinity DataIC50: 30nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194776(CHEMBL3952337)
Affinity DataIC50: 30nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50620113(CHEMBL5420795)
Affinity DataIC50: 30nMAssay Description:Inhibition of PRMT6 (unknown origin) by AlphaLISA assay in vitro assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50095350(CHEMBL3589034)
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 34nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194768(CHEMBL3924657)
Affinity DataIC50: 38nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194775(CHEMBL3943629)
Affinity DataIC50: 40nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194756(CHEMBL3961701)
Affinity DataIC50: 43nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194766(CHEMBL3938938)
Affinity DataIC50: 44nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194781(CHEMBL3929454)
Affinity DataIC50: 46nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194753(CHEMBL3928539)
Affinity DataIC50: 47nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194774(CHEMBL3930600)
Affinity DataIC50: 48nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194729(CHEMBL3948358)
Affinity DataIC50: 48nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50580050(CHEMBL5075218)
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal hexa-His-tagged/TEV cleavage site fused human full length PRMT6 expressed in baculovirus infected Sf9 insect cells using bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194759(CHEMBL3983725)
Affinity DataIC50: 53nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
University of Toronto

LigandPNGBDBM50194762(CHEMBL3892699)
Affinity DataIC50: 56nMAssay Description:Inhibition of human full length PRMT6 (1 to 375 residues) expressed in baculovirus expression system assessed as inhibition of methylation activity p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2018
Entry Details Article
PubMed
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