Compile Data Set for Download or QSAR
Report error Found 1117 Enz. Inhib. hit(s) with Target = 'Protein P'
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092310(US9675697, Cpd. No. 23 | CHEMBL3581661)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to biotinylated PB1BR5 (645 to 766 amino acid residues) (unknown origin) expressed in Rosetta2 cells by bio-layer interferometry met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50098250(CHEMBL3590389)
Affinity DataKd: <1.00E+5nMAssay Description:Binding affinity to PBRM1 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50098305(CHEMBL3590405)
Affinity DataKd:  2.51E+3nMAssay Description:Binding affinity to PBRM1 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50098311(CHEMBL3590408)
Affinity DataKd: <1.00E+5nMAssay Description:Binding affinity to PBRM1 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  48nMAssay Description:Binding affinity to PB1 bromodomain5 (unknown origin) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd: <100nMAssay Description:Binding affinity to human PB1 isoform 5 expressed in BL21 (DE3)-R3-BirA cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50182280(CHEMBL3819245)
Affinity DataKd:  152nMAssay Description:Binding affinity to human PB1 isoform 2 expressed in BL21 (DE3)-R3-BirA cells by isothermal titration CalorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50182280(CHEMBL3819245)
Affinity DataKd:  28nMAssay Description:Binding affinity to human PB1 isoform 5 expressed in BL21 (DE3)-R3-BirA cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50184972(CHEMBL3823525)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50184973(CHEMBL3822828)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50184977(CHEMBL3823132)
Affinity DataKd:  137nMAssay Description:Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50184978(CHEMBL3823524)
Affinity DataKd:  127nMAssay Description:Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50184979(CHEMBL3822689)
Affinity DataKd:  124nMAssay Description:Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50184980(CHEMBL3824067)
Affinity DataKd:  142nMAssay Description:Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50184981(CHEMBL3823055 | US20240190828, Compound 7)
Affinity DataKd:  170nMAssay Description:Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  48nMAssay Description:Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMed
LigandPNGBDBM50285470((9S,11R,19R,20R,23R)-3-Hydroxy-9-methoxy-11,14,19-...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

LigandPNGBDBM50285473((8S,10R,18R,19R,22R)-8-Methoxy-10,13,18-trimethyl-...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

LigandPNGBDBM50030448(CHEMBL269732 | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN ...)
Affinity DataKd:  20nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKd:  4nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

LigandPNGBDBM50285472(18-(E)-allyl-11,21-Dihydroxy-23-[2-((R)-4-hydroxy-...)
Affinity DataKd:  350nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

LigandPNGBDBM50285474((E)-18-Allyl-11,21-dihydroxy-23-[(E)-2-((R)-4-hydr...)
Affinity DataKd:  300nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

LigandPNGBDBM50285471((9S,11R,19R,20R,23R)-15-sec-Butyl-9-methoxy-11,14,...)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to protein phosphatase, calcineurin (CN) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50198438(CHEMBL3904183)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50198451(CHEMBL1491707)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50198448(CHEMBL3966713)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataKd:  1.29E+4nMAssay Description:Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50198440(CHEMBL3945847)
Affinity DataKd:  1.15E+4nMAssay Description:Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50198447(CHEMBL3899245)
Affinity DataKd:  43nMAssay Description:Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50198450(CHEMBL3927964)
Affinity DataKd:  5.10E+3nMAssay Description:Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50198449(CHEMBL3936967)
Affinity DataKd:  3.30E+3nMAssay Description:Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2018
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM220447(US9296741, 36 | US10633379, Compound X)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human PBRM1 bromodomain-2 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM220447(US9296741, 36 | US10633379, Compound X)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human PBRM1 bromodamian-5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50366670(CHEMBL4173488)
Affinity DataKd: >5.00E+3nMAssay Description:Binding affinity to human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50366670(CHEMBL4173488)
Affinity DataKd: >3.00E+3nMAssay Description:Binding affinity to human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by BROMOScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged PBRM1 BD1 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProtein P(DHBV)
Xuzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50290540(CHEMBL4160781)
Affinity DataEC50:  3.42E+4nMAssay Description:Inhibition of DHBV reverse transcriptase polymerase activity expressed in reticulocyte system assessed as reduction in elongation of viral minus stra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged PBRM1 BD5 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM179481(US9675697, Cpd. No. 73)
Affinity DataKd: >4.00E+3nMAssay Description:Binding affinity to human partial length PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM179481(US9675697, Cpd. No. 73)
Affinity DataKd: >4.00E+3nMAssay Description:Binding affinity to human partial length PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length PBRM1 bromodomain 1 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataKd:  8.10E+3nMAssay Description:Binding affinity to human partial length PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProtein P(HBV)
Novira Therapeutics

US Patent
LigandPNGBDBM427204(US10544141, Compound 264)
Affinity DataEC50:  55nMAssay Description:HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetProtein P(HBV)
Novira Therapeutics

US Patent
LigandPNGBDBM427223(US10544141, Compound 441)
Affinity DataEC50:  300nMAssay Description:HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetProtein P(HBV)
Novira Therapeutics

US Patent
LigandPNGBDBM427240(US10544141, Compound 267)
Affinity DataEC50:  300nMAssay Description:HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetProtein P(HBV)
Novira Therapeutics

US Patent
LigandPNGBDBM427466(US10544141, Compound 455)
Affinity DataEC50:  300nMAssay Description:HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetProtein P(HBV)
Novira Therapeutics

US Patent
LigandPNGBDBM427484(US10544141, Compound 274)
Affinity DataEC50:  300nMAssay Description:HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetProtein P(HBV)
Novira Therapeutics

US Patent
LigandPNGBDBM427485(US10544141, Compound 515)
Affinity DataEC50:  300nMAssay Description:HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetProtein P(HBV)
Novira Therapeutics

US Patent
LigandPNGBDBM427486(US10544141, Compound 275)
Affinity DataEC50:  300nMAssay Description:HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetProtein P(HBV)
Novira Therapeutics

US Patent
LigandPNGBDBM427487(US10544141, Compound 546)
Affinity DataEC50:  55nMAssay Description:HBV replication inhibition by the compounds of this invention could be determined in cells infected or transfected with HBV, or cells with stably int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

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