Compile Data Set for Download or QSAR
Report error Found 695 Enz. Inhib. hit(s) with Target = 'Proteasome subunit beta type-1'
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  7.69E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526811(Kzr-616)
Affinity DataIC50: 0.131nMAssay Description:Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50398608(MARIZOMIB)
Affinity DataIC50: 0.604nMAssay Description:Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 3nMAssay Description:Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50: 10nMAssay Description:Inhibition of 20S proteasome beta 2i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50462621(CHEMBL1813256 | MLN-9708 | US11542283, Compound ML...)
Affinity DataIC50: 11nMAssay Description:Inhibition of caspase-like activity of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50462603(CHEMBL4248209 | US11542283, Compound V-8A)
Affinity DataIC50: 13nMAssay Description:Inhibition of caspase-like activity of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50277889(CHEMBL451887 | CARFILZOMIB)
Affinity DataIC50: 13nMAssay Description:Inhibition of human 20S immunoproteasome beta-2i subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 19nMAssay Description:Inhibition of PGPH activity of human 26S proteasome using Z-LLE-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50259656(CHEMBL4089402)
Affinity DataIC50: 20nMAssay Description:Inhibition of caspase-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate after 2 hrs by fluorescence analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50426994(CHEMBL2326533)
Affinity DataIC50: 20nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517598(CHEMBL4543211)
Affinity DataIC50: 22nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517613(CHEMBL4549724)
Affinity DataIC50: 23nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 24nMAssay Description:Inhibition of beta 1 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50426994(CHEMBL2326533)
Affinity DataIC50: 28nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using Bz-VGR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 30nMAssay Description:Inhibition of PGPH-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate pretreated for 2 hrs followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 30nMAssay Description:Inhibition of caspase-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate after 2 hrs by fluorescence analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50259657(CHEMBL4068221)
Affinity DataIC50: 30nMAssay Description:Inhibition of caspase-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate after 2 hrs by fluorescence analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 31nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50: 31nMAssay Description:Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | MLN2238 | Ixazomib | NINLARO | IXA...)
Affinity DataIC50: 31nMAssay Description:Inhibition of beta 1 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50230543(CHEMBL5283576)
Affinity DataIC50: 33nMAssay Description:Inhibition of beta 1 proteasome (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517633(CHEMBL4471150)
Affinity DataIC50: 39nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 44nMAssay Description:Inhibition of caspase-like activity of 20S human proteasome assessed as Z-nLPnLD-AMC hydrolysis at using Promega proteasome-Glo-3 substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517625(CHEMBL4515041)
Affinity DataIC50: 45nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517616(CHEMBL4550571)
Affinity DataIC50: 47nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517649(CHEMBL4457630)
Affinity DataIC50: 47nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50550643(CHEMBL4749207)
Affinity DataIC50: 52nMAssay Description:Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 53nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517612(CHEMBL4577205)
Affinity DataIC50: 57nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50430967(CHEMBL2337848)
Affinity DataIC50: 60nMAssay Description:Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517599(CHEMBL4455846)
Affinity DataIC50: 61nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50259655(CHEMBL4080306)
Affinity DataIC50: 70nMAssay Description:Inhibition of caspase-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate after 2 hrs by fluorescence analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 70nMAssay Description:Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50529640(CHEMBL4452892)
Affinity DataIC50: 71nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50529640(CHEMBL4452892)
Affinity DataIC50: 71nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50259658(CHEMBL4096371)
Affinity DataIC50: 80nMAssay Description:Inhibition of caspase-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate after 2 hrs by fluorescence analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 97nMAssay Description:Inhibition of caspase-like activity of human 20S proteasomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517651(CHEMBL4539247)
Affinity DataIC50: 97nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526813(CHEMBL4465456)
Affinity DataIC50: 97nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526813(CHEMBL4465456)
Affinity DataIC50: 97nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50526813(CHEMBL4465456)
Affinity DataIC50: 97nMAssay Description:Inhibition of 20S proteasome beta 2i (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 104nMAssay Description:Inhibition of human hepatic cell derived 20s constitutive proteasome beta1 caspase-like activity using Suc-LLE-AMC as substrate preincubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 104nMAssay Description:Inhibition of human hepatic cell derived 20s constitutive proteasome beta1 caspase-like activity using Suc-LLE-AMC as substrate preincubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517648(CHEMBL4471154)
Affinity DataIC50: 106nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50259647(CHEMBL4100727)
Affinity DataIC50: 110nMAssay Description:Inhibition of caspase-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate after 2 hrs by fluorescence analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
Hangzhou Xixi Hospital

Curated by ChEMBL
LigandPNGBDBM50517607(CHEMBL4590398)
Affinity DataIC50: 110nMAssay Description:Inhibition of 20S immunoproteasome beta 2 in human Raji cell lysates after 1 hr by competitive ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50593026(CHEMBL5198837)
Affinity DataIC50: 114nMAssay Description:Inhibition of 20S proteasome beta1 subunit (unknown origin) using Z-LLE-AMC as flurogenic substrate measured after 1 hr by fluorescence based analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetProteasome subunit beta type-1(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 120nMAssay Description:Inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate measured for 1 hr b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Displayed 1 to 50 (of 695 total ) | Next | Last >>
Jump to: