Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with Target = 'Proteasome subunit alpha type-6'
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM67544(TRIFLUPROMAZINE | SR-01000000224-4 | N,N-dimethyl-...)
Affinity DataEC50:  7.80E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.60E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  41nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65514(CPZ analog, 8)
Affinity DataEC50:  1.56E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65513(CPZ analog, 7)
Affinity DataEC50:  6.40E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65512(CPZ analog, 6)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65511(CPZ analog, 5)
Affinity DataEC50:  8.90E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65510(CPZ analog, 4)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65508(CPZ analog, 2)
Affinity DataEC50:  6.30E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65507(CPZ analog, 1)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataEC50:  9.90E+3nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataEC50:  1.24E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM79211(METHIXENE | MLS002153842 | cid_71177 | Metixene hy...)
Affinity DataEC50:  1.19E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataEC50:  1.48E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM65509(CPZ analog, 3)
Affinity DataEC50: >2.50E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50002338(10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsul...)
Affinity DataEC50:  1.20E+4nMpH: 7.5 T: 2°CAssay Description:Activity assays were carried out in a 200 uL reaction volume. Different concentrations of test compounds were added to a black flat/clear bottom 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/3/2018
Entry Details Article
PubMed
TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM588478(US11542283, Compound IV-9 | (R)-N-(2,5-dichloroben...)
Affinity DataIC50: 4.86nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50516758(CHEMBL4444471 | US11542283, Compound V-9A)
Affinity DataIC50: 5.69nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM588482(US11542283, Compound V-9B | (R)-N-(2,5-dichloroben...)
Affinity DataIC50: 6.60nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50462603(CHEMBL4248209 | US11542283, Compound V-8A)
Affinity DataIC50: 7.02nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50462621(CHEMBL1813256 | MLN-9708 | US11542283, Compound ML...)
Affinity DataIC50: 7.47nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50462625(CHEMBL4243375 | US11542283, Compound IV-8)
Affinity DataIC50: 7.52nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM588480(US11542283, Compound V-8B | (S)-N-(2,5-dichloroben...)
Affinity DataIC50: 8.20nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50069989(CHEMBL325041 | (R)-3-methyl-1-((S)-3-phenyl-2-(pyr...)
Affinity DataIC50: 9.92nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetProteasome subunit alpha type-6(Human)
Michigan State University

LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 1.31E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed