Compile Data Set for Download or QSAR
Report error Found 1641 Enz. Inhib. hit(s) with Target = 'Proprotein convertase subtilisin/kexin type 9'
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50014066(CHEMBL42526 | 2-Acetylamino-3-(4-oxiranylmethoxy-p...)
Affinity DataKon:  3.50E+3M-1s-1Assay Description:Inhibitory activity against subtilisinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM217366(TVFTSWEEYLDWV | Pep2-8)
Affinity DataKd:  700nMAssay Description:Binding affinity to recombinant human C-terminal His8-tagged PCSK9 expressed in Chinese hamster ovary cells by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50520942(CHEMBL4447311)
Affinity DataKd:  4.12E+4nMAssay Description:Binding affinity to PCSK9 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50520943(CHEMBL4460894)
Affinity DataKd:  3.58E+4nMAssay Description:Binding affinity to PCSK9 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50520944(CHEMBL4440808)
Affinity DataKd:  2.48E+4nMAssay Description:Binding affinity to PCSK9 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50520945(CHEMBL4584571)
Affinity DataEC50:  6.04E+3nMAssay Description:Inhibition of PCSK9 in human HepG2 cells assessed as increase in LDL uptake after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataKd:  1.90E+5nMAssay Description:Inhibition of PCSK9 in human HepG2 cells assessed as increase in LDLR levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50520946(CHEMBL4544205)
Affinity DataKd:  24nMAssay Description:Binding affinity to human recombinant PCSK9 by backscatter interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565588(CHEMBL4779430)
Affinity DataEC50:  348nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565589(CHEMBL4789986)
Affinity DataEC50:  2.5nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565590(CHEMBL4780905)
Affinity DataEC50:  0.150nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565591(CHEMBL4783308)
Affinity DataEC50:  1.20nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565592(CHEMBL4788701)
Affinity DataEC50:  11nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565593(CHEMBL4779800)
Affinity DataEC50:  40nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565594(CHEMBL4783828)
Affinity DataEC50:  88nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565595(CHEMBL4785006)
Affinity DataEC50:  0.280nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565596(CHEMBL4797870)
Affinity DataEC50:  0.690nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM50565597(CHEMBL4783880)
Affinity DataEC50:  161nMAssay Description:Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537863(US11248001, Example 338)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537864(US11248001, Example 339 | US11603523, Example 339)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537865(US11248001, Example 340 | US11603523, Example 340)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537866(US11248001, Example 341 | US11603523, Example 341)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537867(US11248001, Example 342 | US11603523, Example 342)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537868(US11248001, Example 343 | US11603523, Example 343)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537869(US11248001, Example 344 | US11603523, Example 344)
Affinity DataKd:  1.10E+3nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537870(US11248001, Example 345 | US11603523, Example 345)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537871(US11248001, Example 346 | US11603523, Example 346)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537872(US11248001, Example 347 | US11603523, Example 347)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537873(US11248001, Example 348 | US11603523, Example 348)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537874(US11248001, Example 349 | US11603523, Example 349)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537875(US11248001, Example 350 | US11603523, Example 350)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537876(US11248001, Example 351 | US11603523, Example 351)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537877(US11248001, Example 352 | US11603523, Example 352)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537878(US11248001, Example 353)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537879(US11248001, Example 354)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537880(US11248001, Example 355)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537881(US11248001, Example 356)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537882(US11248001, Example 357 | US11603523, Example 357)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537883(US11248001, Example 358 | US11603523, Example 358)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537884(US11248001, Example 359 | US11603523, Example 359)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537885(US11248001, Example 360 | US11603523, Example 360)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537886(US11248001, Example 361 | US11603523, Example 361)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537887(US11248001, Example 362 | US11603523, Example 362)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537888(US11248001, Example 363 | US11603523, Example 363)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537889(US11248001, Example 364 | US11603523, Example 364)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537890(US11248001, Example 365 | US11603523, Example 365)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537891(US11248001, Example 366 | US11603523, Example 366)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537892(US11248001, Example 367 | US11603523, Example 367)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537893(US11248001, Example 368)
Affinity DataKd: <200nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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TargetProprotein convertase subtilisin/kexin type 9(Human)
State University

Curated by ChEMBL
LigandPNGBDBM537894(US11248001, Example 369 | US11603523, Example 369)
Affinity DataKd:  1.10E+4nMAssay Description:Surface plasmon resonance data was collected on a Biacore T200 or 3000 system (GE Healthcare) at 25° C. Streptavidin was immobilized on a CMS (GE Hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
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