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Report error Found 17 Enz. Inhib. hit(s) with Target = 'Proprotein convertase subtilisin/kexin type 7'
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50349829(CHEMBL1813183)
Affinity DataIC50: 462nMAssay Description:Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM35525(dicoumarol | 3,3''''-methylenebis(4-hydroxycoumari...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataIC50: 2.46E+4nMAssay Description:Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50533413(CHEMBL3126388)
Affinity DataKi:  0.120nMAssay Description:Inhibition of recombinant C-terminal truncated human SPC7 expressed in drosophila Schneider 2 cells after 1 hr by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50446944(CHEMBL3115771)
Affinity DataKi:  14nMAssay Description:Inhibition of human PC7 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50446945(CHEMBL3115770)
Affinity DataKi:  72nMAssay Description:Inhibition of human PC7 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50270054(TPRARRRKKRT | CHEMBL502642)
Affinity DataKi:  135nMAssay Description:Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50269901(TPRARRRKKRI | CHEMBL525748)
Affinity DataKi:  135nMAssay Description:Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50270067(TPQRARRRKKRW | CHEMBL503520)
Affinity DataKi:  172nMAssay Description:Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50270060(TPQRARRRKKRT | CHEMBL455792)
Affinity DataKi:  206nMAssay Description:Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50303776(N-((6S,9S,12S)-1,17-diamino-6-(4-carbamimidoylbenz...)
Affinity DataKi:  968nMAssay Description:Inhibition of human PC7 expressed in Drosophila schneider 2 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50270068(TPQRARRRKKRF | CHEMBL500184)
Affinity DataKi:  1.13E+3nMAssay Description:Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50270069(TPQRARRRKKRY | CHEMBL499438)
Affinity DataKi:  1.22E+3nMAssay Description:Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50303775((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Affinity DataKi:  5.13E+3nMAssay Description:Inhibition of human PC7 expressed in Drosophila schneider 2 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50303774(phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide | CH...)
Affinity DataKi:  6.15E+3nMAssay Description:Inhibition of human PC7 expressed in Drosophila schneider 2 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50303777((S)-5-guanidino-N-((S)-1-((S)-5-guanidino-1-(3-gua...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human PC7 expressed in Drosophila schneider 2 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 7(Human)
Universidade Estadual Paulista

Curated by ChEMBL
LigandPNGBDBM50303778((S)-N-((1-carbamimidoylpiperidin-4-yl)methyl)-5-gu...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human PC7 expressed in Drosophila schneider 2 cells by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed