Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with Target = 'Presequence protease, mitochondrial'
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449405BDBM50449405(CHEMBL3127264)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta subunit (2 to 56) after 2.5 hrs by Immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449404BDBM50449404(CHEMBL3127263)
Affinity DataEC50:  57nMAssay Description:Agonist activity at human PreP assessed as degradation of fluorogenic substrate V measured for 10 mins by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449405BDBM50449405(CHEMBL3127264)
Affinity DataEC50:  152nMAssay Description:Agonist activity at human PreP assessed as degradation of fluorogenic substrate V measured for 10 mins by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449404BDBM50449404(CHEMBL3127263)
Affinity DataEC50:  402nMAssay Description:Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid beta (1 to 42) after 2.5 hrs by Immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449404BDBM50449404(CHEMBL3127263)
Affinity DataEC50:  601nMAssay Description:Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta subunit (2 to 56) after 2.5 hrs by Immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50449405BDBM50449405(CHEMBL3127264)
Affinity DataEC50:  713nMAssay Description:Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid beta (1 to 42) after 2.5 hrs by Immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Mouse)
Praxis Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50009366BDBM50009366(CHEMBL3233842 | US9346814, Cmpd No 1, Example 1 | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:PREP enzymatic activity assay. To assay baseline prolyl endopeptidase (PREP) activity, 20 ng of recombinant human PREP (rhPREP) (R&S system, #4308-SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetPresequence protease, mitochondrial(Mouse)
Praxis Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50050513BDBM50050513(Ketopyrrolidine derivative | (R)-1-((S)-2-amino-3-...)
Affinity DataIC50: 5.50E+3nMAssay Description:PREP enzymatic activity assay. To assay baseline prolyl endopeptidase (PREP) activity, 20 ng of recombinant human PREP (rhPREP) (R&S system, #4308-SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetPresequence protease, mitochondrial(Mouse)
Praxis Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 581063BDBM581063(US11504364, Compound 2)
Affinity DataIC50: 1.00E+4nMAssay Description:PREP enzymatic activity assay. To assay baseline prolyl endopeptidase (PREP) activity, 20 ng of recombinant human PREP (rhPREP) (R&S system, #4308-SE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent