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Report error Found 23 Enz. Inhib. hit(s) with Target = 'Presenilins-associated rhomboid-like protein, mitochondrial'
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  4.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50646542(CHEMBL5591199)
Affinity DataEC50:  52nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50646539(CHEMBL5595990)
Affinity DataEC50:  270nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50616103(CHEMBL5419931)
Affinity DataEC50:  445nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50616103(CHEMBL5419931)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant C-terminal hexahistidine tagged mature human PARL using Ac-RRRAVFLA-4mc as substrate preincubated for 1 hr followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50616103(CHEMBL5419931)
Affinity DataIC50: 28nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50616102(CHEMBL5405012)
Affinity DataIC50: 35nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50646540(CHEMBL5590380)
Affinity DataIC50: 42nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50646541(CHEMBL5593588)
Affinity DataIC50: 47nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50646539(CHEMBL5595990)
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50646542(CHEMBL5591199)
Affinity DataIC50: 52nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50646535(CHEMBL5590363)
Affinity DataIC50: 59nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50616104(CHEMBL5428186)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant C-terminal hexahistidine tagged mature human PARL using Ac-RRRAVFLA-4mc as substrate preincubated for 1 hr followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50616103(CHEMBL5419931)
Affinity DataIC50: 150nMAssay Description:Inhibition of human PARL expressed in human HEK293T cells cotransfected human FLAG tagged PGAM5 assessed as inhibition of CCCP induced full length PG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50616103(CHEMBL5419931)
Affinity DataIC50: 410nMAssay Description:Inhibition of tetracycline inducible FLAG tagged human PARL expressed in human PARL knockout Flp-In-T-REx-293 cells cotransfected human PGAM5-Myc ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50572960(CHEMBL4859980)
Affinity DataIC50: 700nMAssay Description:Inhibition of human PARL transfected in HEK293T cell membrane assessed as inhibition of FP-Rh labeling treated with compound for 30 mins prior to FP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50572959(CHEMBL4854450)
Affinity DataIC50: 900nMAssay Description:Inhibition of human PARL transfected in HEK293T cell membrane assessed as inhibition of FP-Rh labeling treated with compound for 30 mins prior to FP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50616105(CHEMBL5432932)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of recombinant C-terminal hexahistidine tagged mature human PARL using Ac-RRRAVFLA-4mc as substrate preincubated for 1 hr followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50572956(CHEMBL4855230)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human PARL transfected in HEK293T cell membrane assessed as inhibition of FP-Rh labeling treated with compound for 30 mins prior to FP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50616104(CHEMBL5428186)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of tetracycline inducible FLAG tagged human PARL expressed in human PARL knockout Flp-In-T-REx-293 cells cotransfected human PGAM5-Myc ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50572955(CHEMBL4861272)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human PARL transfected in HEK293T cell membrane assessed as inhibition of FP-Rh labeling treated with compound for 30 mins prior to FP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50572958(CHEMBL4856971)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of human PARL transfected in HEK293T cell membrane assessed as inhibition of FP-Rh labeling treated with compound for 30 mins prior to FP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetPresenilins-associated rhomboid-like protein, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50572957(CHEMBL4871112)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human PARL transfected in HEK293T cell membrane assessed as inhibition of FP-Rh labeling treated with compound for 30 mins prior to FP-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed