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Report error Found 2076 Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 2'
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86478(A-317491)
Affinity DataKi:  0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118243(MRS 2191 | CHEMBL334823)
Affinity DataEC50:  1.10nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50118232(ATP, 2-meS | CHEMBL336208 | 2-MeSATP)
Affinity DataKi:  2.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50594500(CHEMBL5202979)
Affinity DataIC50: 3.70nMAssay Description:Agonist activity at human P2X2R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86488(NSC_0 | CAS_81790-82-1 | ATP, Bz)
Affinity DataKi:  4.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86483(NSC_175692 | CAS_175692 | AP4A)
Affinity DataKi:  4.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50257829(Ro-51 | 2-(4-amino-5-(5-iodo-2-isopropyl-4-methoxy...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human P2X2/3 receptor expressed in 1321n1c cells by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50594498(CHEMBL4583478)
Affinity DataIC50: 8.30nMAssay Description:Agonist activity at human P2X2R/P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM86478(A-317491)
Affinity DataKi:  9nMAssay Description:Antagonist activity at human P2X2/3 expressed in human1321N1 cells assessed as inhibition of alpha,beta-methylene-ATP-stimulated Ca2+ influx preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM86478(A-317491)
Affinity DataKi:  9nMAssay Description:Antagonist activity at human P2X2/3 expressed in human1321N1 cells assessed as inhibition of alpha,beta-methylene-ATP-stimulated Ca2+ influx preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50026203(({[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxola...)
Affinity DataKi:  10.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50413370(CHEMBL495204)
Affinity DataIC50: 13nMAssay Description:Inhibition of P2X2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86485(NSC_440210 | CAS_440210 | AP5A)
Affinity DataKi:  13.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM319936(US10174016, Example 103 | 3-[(2- Methylpyridin- 4-...)
Affinity DataIC50: 14nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM320093(US10174016, Example 260 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 14nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM320093(US10174016, Example 260 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 14nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM319936(US10174016, Example 103 | 3-[(2- Methylpyridin- 4-...)
Affinity DataIC50: 14nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM320093(US10174016, Example 260 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 14nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM319936(US10174016, Example 103 | 3-[(2- Methylpyridin- 4-...)
Affinity DataIC50: 14nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM320093(US10174016, Example 260 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 14nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM319936(US10174016, Example 103 | 3-[(2- Methylpyridin- 4-...)
Affinity DataIC50: 14nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86486(CAS_644357 | NSC_644357 | ATP,TNP)
Affinity DataKi:  14.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM2(CHEMBL14249 | ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-pu...)
Affinity DataKi:  14.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM319933(US10174016, Example 100 | N-[(1R)-1-(6- Methyl- py...)
Affinity DataIC50: 16nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM319933(US10174016, Example 100 | N-[(1R)-1-(6- Methyl- py...)
Affinity DataIC50: 16nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50413367(CHEMBL523173)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human P2X2/3 receptor expressed in 1321n1c cells by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM319933(US10174016, Example 100 | N-[(1R)-1-(6- Methyl- py...)
Affinity DataIC50: 16nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM319933(US10174016, Example 100 | N-[(1R)-1-(6- Methyl- py...)
Affinity DataIC50: 16nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50413364(CHEMBL492300)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human P2X2/3 receptor expressed in 1321n1c cells by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86482(NSC_123694 | CAS_123694 | AP6A)
Affinity DataKi:  16.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM319940(US10174016, Example 107 | N-[(1R)-1-(6- Methylpyri...)
Affinity DataIC50: 17nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM319940(US10174016, Example 107 | N-[(1R)-1-(6- Methylpyri...)
Affinity DataIC50: 17nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM319940(US10174016, Example 107 | N-[(1R)-1-(6- Methylpyri...)
Affinity DataIC50: 17nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM319940(US10174016, Example 107 | N-[(1R)-1-(6- Methylpyri...)
Affinity DataIC50: 17nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 19nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 19nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 19nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM319931(US10174016, Example 98 | 3-(5-Methyl- 1,3-thiazol-...)
Affinity DataIC50: 19nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM320075(US10174016, Example 242 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 22nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM320075(US10174016, Example 242 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 22nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM320075(US10174016, Example 242 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 22nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM320075(US10174016, Example 242 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 22nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86487(NSC_0 | CAS_0 | ATP,3'-deoxy)
Affinity DataKi:  22.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM320102(US10174016, Example 269 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 23nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM320111(US10174016, Example 278 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 23nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM320111(US10174016, Example 278 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 23nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM320111(US10174016, Example 278 | 3-(5-ethyl-1,3- thiazol-...)
Affinity DataIC50: 23nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86479(NSC_440317 | CAS_440317 | ATP,Gamma S)
Affinity DataKi:  24.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 2(Human)
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50413345(CHEMBL494159)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human P2X2/3 receptor expressed in 1321n1c cells by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetP2X purinoceptor 2/3(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM319958(US10174016, Example 125 | 3-(5-Ethyl-1,3-thiazol-2...)
Affinity DataIC50: 27nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

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