Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with Target = 'Oxysterols receptor LXR-alpha/LXR-beta'
TargetOxysterols receptor LXR-alpha/LXR-beta(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50177015(CHEMBL3814206 | US10144715, Compound 19-1)
Affinity DataEC50:  4nMAssay Description:Agonist activity at LXR in human THP1 cells assessed as upregulation of ABCA1 gene expression after 24 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxysterols receptor LXR-alpha/LXR-beta(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50177015(CHEMBL3814206 | US10144715, Compound 19-1)
Affinity DataEC50:  6nMAssay Description:Agonist activity at LXR in human HepG2 cells assessed as upregulation of SREBP1C gene expression after 24 hrs by RT-PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxysterols receptor LXR-alpha/LXR-beta(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM28802(2-{[(5-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human LXR by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2017
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/LXR-beta(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50122619(CHEMBL3623107)
Affinity DataIC50: 1.50E+3nMAssay Description:Transrepression activity of LXR in human THP1 cells assessed as inhibition of LPS-induced IL-6 level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/LXR-beta(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50396601(CHEMBL2171902)
Affinity DataIC50: 1.70E+3nMAssay Description:Transrepression activity of LXR in human THP1 cells assessed as inhibition of LPS-induced IL-6 level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha/LXR-beta(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | [3H]T0901317 | T 0901317 | N-[4-(1,1...)
Affinity DataIC50: 2.60E+4nMAssay Description:Transrepression activity of LXR in human THP1 cells assessed as inhibition of LPS-induced IL-6 level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)