Compile Data Set for Download or QSAR
Report error Found 169 Enz. Inhib. hit(s) with Target = 'Orf1a protein'
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM674654(US20240158368, Compound 1)
Affinity DataEC50:  1.02nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM674655(US20240158368, Compound 2)
Affinity DataEC50:  1.35nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM674656(US20240158368, Compound 3)
Affinity DataEC50:  1.23nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM674657(US20240158368, Compound 4)
Affinity DataEC50:  12.3nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM674658(US20240158368, Compound 5)
Affinity DataEC50:  1.26nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM674659(US20240158368, Compound 6)
Affinity DataEC50:  2.51nMAssay Description:SARS-CoV-2 Mpro biochemical assays were performed in 8 μL in 384-well Proxi-Plus plate (PerkinElmer, Waltham, MA USA) at ambient temperature in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM419123(3CLpro inhibitor 7a)
Affinity DataEC50:  80nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM419124(3CLpro inhibitor 6c)
Affinity DataEC50:  50nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM419128(3CLpro inhibitor 7e)
Affinity DataEC50:  530nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM419130(3CLpro inhibitor 7h)
Affinity DataEC50:  210nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM419131(3CLpro inhibitor 6j | 3CLpro inhibitor 7j)
Affinity DataEC50:  40nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM419133(GC376 | BDBM429386 | US12180156, BS of GC373)
Affinity DataEC50:  900nMAssay Description:Some compounds in the 6a to 6k and 7a to 7k series were also investigated for their antiviral activity against the replication of MERS-CoV, FIPV, or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM429387(med.21724, Compound 58)
Affinity DataEC50:  500nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM429388(med.21724, Compound 59)
Affinity DataEC50:  800nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM22985(Aralen | Chlorochin | CHLOROQUINE PHOSPHATE | Chlo...)
Affinity DataEC50:  3.00E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataEC50:  4.90E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataEC50:  4.80E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50180655(CHEBI:31781 | A-157378-0 | A-157378.0 | ABT-378 | ...)
Affinity DataEC50:  8.00E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM31197(CHEMBL211045 | Nutlin-3 | med.21724, Compound 186)
Affinity DataEC50:  3.69E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM22875(Vistaril | CHEMBL896 | 2-(2-{4-[(4-chlorophenyl)(p...)
Affinity DataEC50:  1.44E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM586429(Amodiaquin | USRE49340, Rank 6 | BDBM50041457)
Affinity DataEC50:  2.10E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataEC50:  2.90E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM33971(Sotrastaurin | AEB071 | med.21724, Compound 190)
Affinity DataEC50:  9.70E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM82475(CAS_5714-00-1 | NSC_17676 | ACETOPHENAZINE | med.2...)
Affinity DataEC50:  2.36E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50418049(CL 36467 | CL 39743 | LEVOMEPROMAZINE | med.21724,...)
Affinity DataEC50:  2.50E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM429518(med.21724, Compound 193)
Affinity DataEC50:  3.40E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM38871(cid_6603320 | SMR000058444 | EMETINE HYDROCHLORIDE...)
Affinity DataEC50:  14nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM22985(Aralen | Chlorochin | CHLOROQUINE PHOSPHATE | Chlo...)
Affinity DataEC50:  6.27E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50467780(CHEBI:5801 | Hydroxychloroquine | med.21724, Compo...)
Affinity DataEC50:  8.27E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50022889(CHEMBL416956 | [2,8-bis(trifluoromethyl)quinolin-4...)
Affinity DataEC50:  7.41E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM586429(Amodiaquin | USRE49340, Rank 6 | BDBM50041457)
Affinity DataEC50:  6.21E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50017698(cid_71420 | Imodium | 4-[4-(4-Chloro-phenyl)-4-hyd...)
Affinity DataEC50:  4.80E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50180655(CHEBI:31781 | A-157378-0 | A-157378.0 | ABT-378 | ...)
Affinity DataEC50:  8.00E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM429291(med.21724, Compound 27)
Affinity DataEC50:  1.27E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM429521(med.21724, Compound Gemcitabine)
Affinity DataEC50:  1.21E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataEC50:  1.01E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM58492(2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]...)
Affinity DataEC50:  1.29E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50375318(Fungistat | Gyno-Terazol | Panlomyc | R-42470 | Te...)
Affinity DataEC50:  1.22E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50170637(2-(4-Chloro-phenyl)-1-[4-(2-diethylamino-ethoxy)-p...)
Affinity DataEC50:  5.28E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM63919(acetic acid [(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphe...)
Affinity DataEC50:  3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50080528(Cycloheximid | 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2...)
Affinity DataEC50:  189nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50480293(CHEBI:71019 | CGX-635 | Homoharringtonine | NSC-14...)
Affinity DataEC50:  71nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM429529(med.21724, Compound Benztropine)
Affinity DataEC50:  1.66E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM26948(CHEMBL46516 | cid_3396 | FLUSPIRILENE | 8-[4,4-bis...)
Affinity DataEC50:  7.47E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM78576(MLS000028463 | cid_941651 | SMR000058396 | CIS-THI...)
Affinity DataEC50:  9.29E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50001888([3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-...)
Affinity DataEC50:  9.51E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]pro...)
Affinity DataEC50:  5.86E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM50017696(N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamin...)
Affinity DataEC50:  1.18E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM24226(cid_2247 | [3H]-ASTEMIZOLE | Hismanal | ASTEMIZOLE...)
Affinity DataEC50:  4.88E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
Abbvie

US Patent
LigandPNGBDBM429534(med.21724, Compound Chlorphenoxamine)
Affinity DataEC50:  1.26E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
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