Compile Data Set for Download or QSAR
Report error Found 13537 Enz. Inhib. hit(s) with Target = 'Orexin receptor type 2'
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559715(WO2022109117, Example 60)
Affinity DataIC50: 0.0400nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50601261(CHEMBL5196538)
Affinity DataIC50: 0.0400nMAssay Description:Agonist activity at human OX2R expressed in CHO cells incubated for 2 hrs by IP-one detection reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559716(WO2022109117, Example 61)
Affinity DataIC50: 0.0500nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50601262(CHEMBL5194793)
Affinity DataIC50: 0.0500nMAssay Description:Agonist activity at human OX2R expressed in CHO cells incubated for 2 hrs by IP-one detection reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121759([D-Leu15]orexin-B | CHEMBL438587)
Affinity DataEC50:  0.0520nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM386188((2R,3S)-N-ethyl-2-(((cis-4-(3- fluorophenyl)cycloh...)
Affinity DataEC50:  0.0530nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM386188((2R,3S)-N-ethyl-2-(((cis-4-(3- fluorophenyl)cycloh...)
Affinity DataEC50:  0.0530nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM386188((2R,3S)-N-ethyl-2-(((cis-4-(3- fluorophenyl)cycloh...)
Affinity DataEC50:  0.0530nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121770([Ala14]orexin-B | CHEMBL413504)
Affinity DataEC50:  0.0650nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121788([Ala11]orexin-B | CHEMBL441918)
Affinity DataEC50:  0.0660nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559737(WO2022109117, Example 82)
Affinity DataIC50: 0.0700nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50601264(CHEMBL5177846)
Affinity DataIC50: 0.0700nMAssay Description:Agonist activity at human OX2R expressed in CHO cells incubated for 2 hrs by IP-one detection reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50444605(CHEMBL3099899)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [3H]SB-674042 from human orexin-2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetOrexin receptor type 2(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50417257(SB-649868)
Affinity DataKi:  0.0776nMAssay Description:Antagonist activity at recombinant rat OX2R expressed in CHO cells by FLIPR calcium based functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetOrexin receptor type 2(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM104700(US8569311, 1-10)
Affinity DataKi:  0.0800nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121783(Orexin-B | CHEMBL413434)
Affinity DataEC50:  0.0810nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121775([D-Leu7]orexin-B | CHEMBL438036)
Affinity DataEC50:  0.0840nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50601259(CHEMBL5195414)
Affinity DataIC50: 0.0900nMAssay Description:Agonist activity at human OX2R expressed in CHO cells incubated for 2 hrs by IP-one detection reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559656(WO2022109117, Example 1)
Affinity DataIC50: 0.0900nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50374443(CHEMBL272715)
Affinity DataKi:  0.0900nMAssay Description:Displacement of [3H](S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2R exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121795([Gly17]orexin-B | CHEMBL436915)
Affinity DataEC50:  0.0910nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559670(WO2022109117, Example 17 | WO2022109117, Example 1...)
Affinity DataIC50: 0.100nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559734(WO2022109117, Example 79)
Affinity DataIC50: 0.100nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM205260(US9546152, example 95)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which the inhibition constant (Ki) is determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2018
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50601260(CHEMBL5190821)
Affinity DataIC50: 0.100nMAssay Description:Agonist activity at human OX2R expressed in CHO cells incubated for 2 hrs by IP-one detection reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM205108(US9546152, example 18 | 2-{[(3r,6r)-1-{[2-fluoro-6...)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which the inhibition constant (Ki) is determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2018
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50601263(CHEMBL5206338)
Affinity DataIC50: 0.100nMAssay Description:Agonist activity at human OX2R expressed in CHO cells incubated for 2 hrs by IP-one detection reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM205245(US9546152, example 93 | 3-ethyl-2-{[(3r,6r)-6- met...)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which the inhibition constant (Ki) is determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2018
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559675(WO2022109117, Example 20)
Affinity DataIC50: 0.100nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50374442(CHEMBL255763)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H](S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-(1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2R exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM205119(US9546152, example 28 | 2-{[(3r,6r)-1-{[5-fluoro-2...)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which the inhibition constant (Ki) is determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2018
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM205137(US9546152, example 44 | 3-methyl-2-{[(3r,6r)-6- me...)
Affinity DataKi:  0.100nMAssay Description:Radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which the inhibition constant (Ki) is determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2018
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50148575(CHEMBL3770503)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to OX2R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2017
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559657(WO2022109117, Example 2)
Affinity DataIC50: 0.110nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121769([D-Gln12]orexin-B | CHEMBL428123)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM120778(US8710076, F-2)
Affinity DataKi:  0.110nMAssay Description:Compound potency can be assessed by a radioligand binding assay (described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430) in which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50:  0.110nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50:  0.110nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559745(WO2022109117, Example 90)
Affinity DataIC50: 0.110nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559711(WO2022109117, Example 56)
Affinity DataIC50: 0.110nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM386162(cis-N-ethyl-2-(((cis-4-(2- fluorophenyl)cyclohexyl...)
Affinity DataEC50:  0.120nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121815([Ala6]orexin-B | CHEMBL410480)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM386162(cis-N-ethyl-2-(((cis-4-(2- fluorophenyl)cyclohexyl...)
Affinity DataEC50:  0.120nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM386162(cis-N-ethyl-2-(((cis-4-(2- fluorophenyl)cyclohexyl...)
Affinity DataEC50:  0.120nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121794([Ala7]orexin-B | CHEMBL427771)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559747(WO2022109117, Example 92)
Affinity DataIC50: 0.130nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121796([Ala16]orexin-B | CHEMBL414312)
Affinity DataEC50:  0.130nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121810([D-Ala9]orexin-B | CHEMBL409301)
Affinity DataEC50:  0.130nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM50121765([Ala13]orexin-B | CHEMBL437464)
Affinity DataEC50:  0.130nMAssay Description:Agonist activity against human orexin 2 receptor; EC50; nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM559712(WO2022109117, Example 57)
Affinity DataIC50: 0.130nMAssay Description:In a typical experiment, the OXI and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
WIPO WO2022109117

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