Compile Data Set for Download or QSAR
Report error Found 55 Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2 [871-1187]'
LigandPNGBDBM449883(US10703751, Example 641 of WO2011086053)
Affinity DataEC50:  115nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM50434787(CHEMBL2386635 | US10703751, Example 644 of WO20110...)
Affinity DataEC50:  3.32nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM449881(cis-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(methylamino)i...)
Affinity DataEC50:  443nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataKd:  376nMAssay Description:JAK3 (IC50): Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) is purchased from Invitrogen. 0.025 mU of JAK3 is ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM449875(US10703751, Example 5 | trans-2-[4-[2-[1-Hydroxyet...)
Affinity DataEC50:  111nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM449880(cis-2-[4-[2-[1-Hydroxyethyl]-6-(methylamino)imidaz...)
Affinity DataEC50:  1.11E+3nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM449875(US10703751, Example 5 | trans-2-[4-[2-[1-Hydroxyet...)
Affinity DataEC50:  102nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM449878(trans-2-[4-[2-[(1R)-1-Hydroxyethyl]-6-(trideuterio...)
Affinity DataEC50:  43nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  32nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM449876(US10703751, Example 3 | trans-2-[4-[2-[(1S)-1-Hydr...)
Affinity DataEC50:  466nMAssay Description:Human baculovirus-expressed Janus kinase (JAK) 1, 2, 3 and tyrosin kinase (TYK) 2 were purchased from Carna Biosciences, Inc (#08-144, -045, -046, -1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 72.7nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
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LigandPNGBDBM103727(US8563545, 1 | US10112907, Example 00033 | US10206...)
Affinity DataIC50: 78nMAssay Description:JAK2 (Kd): JAK2 (Invitrogen, PV4210) is used at a final concentration of 5 nM. The binding experiment is performed in 50 mM Hepes pH 7.5, 0.01% Brij-...More data for this Ligand-Target Pair
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Date in BDB:
3/8/2021
Entry Details
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LigandPNGBDBM349171(2-{4-[2- (Cyclopropanecarbonyl- amino)-[1,2,4]tria...)
Affinity DataIC50: 100nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM349167(Cyclopropanecarboxylic acid {5-[4-(isoxazol-3- yla...)
Affinity DataIC50: 100nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM349137(Cyclopropanecarboxylic acid (5-[4-(3,3-difluoro- p...)
Affinity DataIC50: 100nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM294916(US10112907, Example 00027 | US10206907, Compound 1...)
Affinity DataIC50: 100nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM103737(US8563545, 11 | US10206907, Compound 234 | US11000...)
Affinity DataIC50: 126nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
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LigandPNGBDBM128101(US8796457, 1 | US9505754, 1 | US10206907, Compound...)
Affinity DataIC50: 219nMpH: 7.5 T: 2°CAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
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LigandPNGBDBM349182(Cyclopropanecarboxylic acid (5-{4-[2-(3,3-difluoro...)
Affinity DataIC50: 300nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM349184(Cyclopropanecarboxylic acid (5-{4-[2-oxo-2-(4- tri...)
Affinity DataIC50: 300nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348922(N-(5-(4-(pyridin-3- ylmethoxy)phenyl)- [1,2,4]tria...)
Affinity DataIC50: 300nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348940(N-(5-(4-(2- fluorophenylsulfonamido) phenyl)-[1,2,...)
Affinity DataIC50: 300nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348919(N-(5-(4-(4- fluorophenylsulfonamido) phenyl)-[1,2,...)
Affinity DataIC50: 300nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM349038(N-(5-(4-(4-benzyl-4- hydroxypiperidine-1- carbonyl...)
Affinity DataIC50: 300nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM50031742(CHEMBL3360348 | US10206907, Compound 59)
Affinity DataIC50: 300nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348952(N-(5-(4-(pyridin-3-yl)phenyl)- [1,2,4]triazolo[1,5...)
Affinity DataIC50: 750nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348946(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Affinity DataIC50: 750nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348900(N-(5-(4-(N- cyclopropylsulfamoyl)phenyl)- [1,2,4]t...)
Affinity DataIC50: 750nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348903(N-(5-(4-(piperidine-1- carbonyl(phenyl)- [1,2,4]tr...)
Affinity DataIC50: 750nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348923(N-(5-(4-(pyridin-2- ylmethoxy)phenyl)- [1,2,4]tria...)
Affinity DataIC50: 750nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348926(N-(5-(4- (cyclopentyloxy)phenyl)- [1,2,4]triazolo[...)
Affinity DataIC50: 750nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348938(N-(5-(4-((5-methylisoxazol-3- yl)methoxy)phenyl)- ...)
Affinity DataIC50: 750nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348937(N-(5-(4-(2-(3,5-dimethyl-1H- pyrazol-4-yl)ethyldim...)
Affinity DataIC50: 750nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348886(N-(5-(4-(4-methylpiperazin-1- yl)phenyl)-[1,2,4]tr...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348948(N-(5-(4-((1,5-dimethyl-1H- pyrazol-3-yl)methyldime...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348902(N-(5-(4-(benzyloxy)-3- fluorophenyl)- [1,2,4]triaz...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM103728(US8563545, 2 | US10206907, Compound 18 | US1100052...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348925(N-(5-(4- (cyclobutylmethoxy)phenyl)- [1,2,4]triazo...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348927(N-(5-(4- (cyclohexylmethoxy)phenyl)- [1,2,4]triazo...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348928(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348929(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348932(N-(5-(4-phenoxyphenyl)- [1,2,4]triazolo[1,5-a]pyri...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348934(N-(5-(4-((1-methyl-1H- pyrazol-3-yl)methylmethyl- ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348935(N-(5-(4-((3,5- dimethylisoxazol-4- yl)methoxy)phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348936(N-(5-(4-((1,3-dimethyl-1H- pyrazol-5-yl)methyldime...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348942(N-benzyl-4-(2- (cyclopropanecarboxamido)- [1,2,4]t...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348943(Cyclopropanecarboxylic Acid [5-(6-benzyloxy-pyridi...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348899(US10206907, Compound 163 | N-(5-(4-(benzyloxy)phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM348944(N-(5-(4-(1,2,3,4- tetrahydroisoquinoline-2- carbon...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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LigandPNGBDBM349003(Cyclopropanecarboxylic Acid [5-(1-benzyl-1H-indol-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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