Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2 [580-1182]'
TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM420028(US10487083, Example B)
Affinity DataIC50: 0.200nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50434787(CHEMBL2386635 | US10703751, Example 644 of WO20110...)
Affinity DataIC50: 0.200nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505106(US11066406, C)
Affinity DataIC50: 0.200nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505105(US11066406, B)
Affinity DataIC50: 0.200nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505104(US11066406, A)
Affinity DataIC50: 0.900nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387815(US10294226, Compound A | US10487083, Example A | U...)
Affinity DataIC50: 0.900nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387823(US10294226, Compound Ex. 6 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 1.10nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505112(US11066406, Ex. 6)
Affinity DataIC50: 1.10nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505108(US11066406, Ex. 2)
Affinity DataIC50: 1.5nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505117(US11066406, Ex. 11)
Affinity DataIC50: 1.5nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387828(US10294226, Compound Ex. 11 | 2-(1-((1r,4r)-4-(Cya...)
Affinity DataIC50: 1.5nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387819(US10294226, Compound Ex. 2 | 2-((1r,4r)-4-(2-(1H-I...)
Affinity DataIC50: 1.5nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505110(US11066406, Ex. 4)
Affinity DataIC50: 2.20nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387821(US10294226, Compound Ex. 4 | N-(2-Cyanoethyl)-2-(1...)
Affinity DataIC50: 2.20nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387822(US10294226, Compound Ex. 5 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 4.10nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505111(US11066406, Ex. 5)
Affinity DataIC50: 4.10nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505115(US11066406, Ex. 9)
Affinity DataIC50: 4.70nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387826(US10294226, Compound Ex. 9 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 4.70nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505113(US11066406, Ex. 7)
Affinity DataIC50: 4.80nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387824(US10294226, Compound Ex. 7 | N-(2-Cyano-2-methylpr...)
Affinity DataIC50: 4.80nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505114(US11066406, Ex. 8)
Affinity DataIC50: 6.60nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387825(US10294226, Compound Ex. 8 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 6.60nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505107(US11066406, Ex. 1)
Affinity DataIC50: 7.40nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387818(US10294226, Compound Ex. 1 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 7.40nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387829(US10294226, Compound Ex. 12 | 2-(1-((1r,4r)-4-(Cya...)
Affinity DataIC50: 8.70nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505118(US11066406, Ex. 12)
Affinity DataIC50: 8.70nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505116(US11066406, Ex. 10)
Affinity DataIC50: 9nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387827(US10294226, Compound Ex. 10 | N-(4-(Cyanomethyl)bi...)
Affinity DataIC50: 9nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM505109(US11066406, Ex. 3)
Affinity DataIC50: 11.6nMAssay Description:Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2021
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [580-1182](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM387820(US10294226, Compound Ex. 3 | 2-(1-((1r,4r)-4-(Cyan...)
Affinity DataIC50: 11.6nMAssay Description:11-point dosing series were made for each compound by serially diluting 1:3 or 1:4 in DMSO, with point 12 being a DMSO control. From the serial dilut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
Go to US Patent