Compile Data Set for Download or QSAR
Report error Found 174 Enz. Inhib. hit(s) with Target = 'NAD-dependent protein deacylase sirtuin-6'
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  2.90E+4nMAssay Description:Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of ADP-ribose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  3.30E+4nMAssay Description:Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of ADP-ribose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  2.27E+5nMAssay Description:Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins by fluorescence-based SDS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataKd:  4.45E+5nMAssay Description:Binding affinity to recombinant human full length SIRT6 (1 to 355 residues) expressed in Escherichia coli M15 after 20 mins in presence of NAM by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528214(CHEMBL4592529)
Affinity DataEC50:  2.18E+5nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528216(CHEMBL4440358)
Affinity DataEC50:  5.70E+3nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528217(CHEMBL4538188)
Affinity DataEC50:  1.74E+5nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataEC50:  1.03E+4nMAssay Description:Inhibition of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50540048(CHEMBL4636092)
Affinity DataEC50:  3.80E+4nMAssay Description:Inhibition of sirtuin 6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50544037(CHEMBL1370863)
Affinity DataKd:  9.76E+3nMAssay Description:Binding affinity to SIRT6 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50544037(CHEMBL1370863)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to SIRT6 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataEC50:  1.03E+4nMAssay Description:Allosteric activation of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50540048(CHEMBL4636092)
Affinity DataEC50:  3.80E+4nMAssay Description:Activation of SIRT6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataEC50:  5.35E+3nMAssay Description:Activation of N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] assessed as increase in peptide demyristoylation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataEC50:  8.91E+3nMAssay Description:Activation of N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] assessed as increase in deacetylation activity incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataEC50:  5.49E+3nMAssay Description:Activation of N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] assessed as increase in deacetylation activity incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataKd:  8.85E+3nMAssay Description:Binding affinity to N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50544391(CHEMBL4636189)
Affinity DataKd:  5.52E+3nMAssay Description:Binding affinity to N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataKd:  9.51E+3nMAssay Description:Binding affinity to N-terminal his-tagged human SIRT6 expressed in Escherichia coli M15 [pREP4] by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM86704(CAS_93957-54-1 | Fluvastatin | cid_446155)
Affinity DataEC50:  7.10E+3nMAssay Description:Activation of recombinant SIRT6 (unknown origin) using fluoro substrate peptide incubated for 1 hr in presence of NAD by Fluor de Lys assay based flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM86704(CAS_93957-54-1 | Fluvastatin | cid_446155)
Affinity DataEC50: >2.50E+5nMAssay Description:Activation of N-terminal His-tagged human SIRT6 (1 to 355 residues) expressed in Escherichia coli M15(pREP4) assessed as increase in deacetylation ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528216(CHEMBL4440358)
Affinity DataEC50:  1.00E+4nMAssay Description:Activation of wild type full length human SIRT6 expressed in Escherichia coli BL21(DE3) using RHKK-ac-AMC as substrate incubated for 2 hrs in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50540048(CHEMBL4636092)
Affinity DataEC50:  3.80E+4nMAssay Description:Activation of human SIRT6 using acetylated histone H3K9 as peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528216(CHEMBL4440358)
Affinity DataEC50:  5.70E+3nMAssay Description:Activation of wild type human N-terminal full length SIRT6 deacetylation (8 to 533 residues) expressed in Escherichia coli BL21 (DE3) expression syst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50147581(n-tetradecanoic acid | tetradecoic acid | myristic...)
Affinity DataEC50:  2.46E+5nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activity using H3K9Ac peptide substrate by reversed-phase HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM29080(Oleamide MEA | Oleoyl monoethanolamide | CHEMBL280...)
Affinity DataEC50:  3.10E+3nMAssay Description:Activation of his6-tagged SIRT6 (unknown origin) using H3K9Ac peptide substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50462423(Cyanidin Chloride)
Affinity DataEC50:  4.60E+5nMAssay Description:Activation of human SIRT6 deacetylase activity by FDL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50528218(CHEMBL4551664)
Affinity DataEC50:  1.03E+4nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50408839(CHEMBL5275868)
Affinity DataEC50:  5.30E+3nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50540048(CHEMBL4636092)
Affinity DataEC50:  3.80E+4nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50625192(CHEMBL5396235)
Affinity DataEC50:  6.47E+4nMAssay Description:Activation of recombinant SIRT6 (unknown origin) deacetylase activity using fluoro peptide as substrate by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50625193(CHEMBL5396863)
Affinity DataEC50:  3.88E+4nMAssay Description:Activation of recombinant SIRT6 (unknown origin) deacetylase activity using fluoro peptide as substrate by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50625194(CHEMBL5407488)
Affinity DataEC50:  4.88E+4nMAssay Description:Activation of recombinant SIRT6 (unknown origin) deacetylase activity using fluoro peptide as substrate by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50625195(CHEMBL5419516)
Affinity DataEC50:  5.80E+4nMAssay Description:Activation of recombinant SIRT6 (unknown origin) deacetylase activity using fluoro peptide as substrate by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50625196(CHEMBL5410148)
Affinity DataEC50:  4.86E+4nMAssay Description:Activation of recombinant SIRT6 (unknown origin) deacetylase activity using fluoro peptide as substrate by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50625197(CHEMBL5425666)
Affinity DataEC50:  5.25E+4nMAssay Description:Activation of recombinant SIRT6 (unknown origin) deacetylase activity using fluoro peptide as substrate by microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50462423(Cyanidin Chloride)
Affinity DataEC50:  4.60E+5nMAssay Description:Activation of GST-tagged SIRT6 (unknown origin) deacetylase activity using H3K9Ac peptide substrate by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM15236(CHEMBL164 | Cannabiscetin | 3,5,7-trihydroxy-2-(3,...)
Affinity DataEC50:  4.04E+5nMAssay Description:Activation of GST-tagged SIRT6 (unknown origin) deacetylase activity using H3K9Ac peptide substrate by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50326997(CHEMBL590878 | Delphinidin)
Affinity DataEC50:  7.60E+5nMAssay Description:Activation of GST-tagged SIRT6 (unknown origin) deacetylase activity using H3K9Ac peptide substrate by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM29080(Oleamide MEA | Oleoyl monoethanolamide | CHEMBL280...)
Affinity DataEC50:  3.10E+3nMAssay Description:Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataEC50:  8.90E+4nMAssay Description:Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM22231(CHEMBL267476 | (9Z,12Z)-octadeca-9,12-dienoic acid...)
Affinity DataEC50:  2.30E+5nMAssay Description:Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataEC50:  2.70E+5nMAssay Description:Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;...)
Affinity DataEC50:  9.90E+5nMAssay Description:Activation of human SIRT6 deacetylase activity expressed in Escherichia coli BL21(DE3) expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50147581(n-tetradecanoic acid | tetradecoic acid | myristic...)
Affinity DataEC50:  2.46E+5nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50150484(CHEMBL8659 | oleaic acid | Octadec-9-enoic acid | ...)
Affinity DataEC50:  9.00E+4nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM22231(CHEMBL267476 | (9Z,12Z)-octadeca-9,12-dienoic acid...)
Affinity DataEC50:  1.00E+5nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM29080(Oleamide MEA | Oleoyl monoethanolamide | CHEMBL280...)
Affinity DataEC50:  3.10E+3nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50408838(CHEMBL5277451)
Affinity DataEC50:  7.50E+3nMAssay Description:Activation of recombinant His-tagged SIRT6 (unknown origin) deacetylase activity expressed in Escherichia coli using H3K9Ac peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
University of Bayreuth

Curated by ChEMBL
LigandPNGBDBM50540048(CHEMBL4636092)
Affinity DataEC50:  3.80E+4nMAssay Description:Activation of SIRT6 (unknown origin) deacetylase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
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