Compile Data Set for Download or QSAR
Report error Found 788 Enz. Inhib. hit(s) with Target = 'NAD(+) hydrolase SARM1'
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660053BDBM50660053(CHEMBL6143553)
Affinity DataKd:  12nMAssay Description:Binding affinity to human SARM1 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776382BDBM776382((3R,4S)-4-(4-chlorophenyl)-1-(3-pyridazin-4-yl-1H-...)
Affinity DataIC50: 30nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660042BDBM50660042(CHEMBL6146508)
Affinity DataKd: <33nMAssay Description:Binding affinity to human SARM1 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660055BDBM50660055(CHEMBL6159835)
Affinity DataKd:  38nMAssay Description:Binding affinity to human SARM1 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660069BDBM50660069(CHEMBL6162644)
Affinity DataKd:  39nMAssay Description:Binding affinity to human SARM1 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776374BDBM776374([(3R,4S)-3-(4-chlorophenyl)-4-methyl-pyrrolidin-1-...)
Affinity DataIC50: 51nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776350BDBM776350([(3S)-3-(3,4-difluorophenyl)pyrrolidin-1-yl]-(3-py...)
Affinity DataIC50: 57nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776359BDBM776359((4-chloro-3-pyridazin-4-yl-1H-pyrazol-5-yl)-[(3R)-...)
Affinity DataIC50: 68nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776383BDBM776383([(3R,4S)-3-(3,4-difluorophenyl)-4-methyl-pyrrolidi...)
Affinity DataIC50: 72nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776369BDBM776369([(3R,4S)-3-(4-chlorophenyl)-4-(hydroxymethyl)pyrro...)
Affinity DataIC50: 72nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776348BDBM776348([3-(4-chloro-3-fluoro-phenyl)pyrrolidin-1-yl]-(3-p...)
Affinity DataIC50: 73nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776362BDBM776362([(3S,4R)-3-(4-bromophenyl)-4-methyl-pyrrolidin-1-y...)
Affinity DataIC50: 84nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776387BDBM776387([(3S,4R)-3-(3,4-difluorophenyl)-4-(hydroxymethyl)p...)
Affinity DataIC50: 93nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776372BDBM776372([(3R)-3-(4-chlorophenyl)pyrrolidin-1-yl]-(4-fluoro...)
Affinity DataIC50: 95nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776319BDBM776319([3-(5-chloro-2-thienyl)pyrrolidin-1-yl]-(3-pyridaz...)
Affinity DataIC50: 98nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 615974BDBM615974(US20230271957, Example 3)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 618465BDBM618465(US20230286978, Example 1)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco s PBS buffer in a final assay volume of 20 µL. ARM-SAM-TIR lysate wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616002BDBM616002(US20230271957, Example 6)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 615970BDBM615970(US20230271957, Example 2)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616034BDBM616034(US20230271957, Example 11)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616035BDBM616035(US20230271957, Example 12)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616036BDBM616036(US20230271957, Example 13)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 618474BDBM618474(US20230286978, Example 10)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco s PBS buffer in a final assay volume of 20 µL. ARM-SAM-TIR lysate wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616037BDBM616037(US20230271957, Example 14)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616017BDBM616017(US20230271957, Example 7)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 618468BDBM618468(US20230286978, Example 4)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco s PBS buffer in a final assay volume of 20 µL. ARM-SAM-TIR lysate wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 618469BDBM618469(US20230286978, Example 5)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco s PBS buffer in a final assay volume of 20 µL. ARM-SAM-TIR lysate wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616032BDBM616032(US20230271957, Example 9)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616033BDBM616033(US20230271957, Example 10)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616042BDBM616042(US20230271957, Example 19)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616038BDBM616038(US20230271957, Example 15)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 618476BDBM618476(US20230286978, Example 12)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco s PBS buffer in a final assay volume of 20 µL. ARM-SAM-TIR lysate wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616039BDBM616039(US20230271957, Example 16)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 616040BDBM616040(US20230271957, Example 17)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay was performed in a 384-well polypropylene plate in Dulbecco's PBS buffer in a final assay volume of 20 μL. ARM-SAM-TIR l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2023
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776326BDBM776326([3-(3,4-difluorophenyl)pyrrolidin-1-yl]-(3-pyridaz...)
Affinity DataIC50: 105nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776353BDBM776353([3-(5-bromo-2-thienyl)pyrrolidin-1-yl]-(3-pyridazi...)
Affinity DataIC50: 114nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776356BDBM776356((4-chloro-3-pyridazin-4-yl-1H-pyrazol-5-yl)-[3-(3,...)
Affinity DataIC50: 142nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660068BDBM50660068(CHEMBL6160306)
Affinity DataIC50: 158nMAssay Description:Inhibition of human SARM1 extracted from HEK293 cell lysate in presence of NAD by biochemical (Fluorescence Readout) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776339BDBM776339([(3R,4S)-3-(4-chlorophenyl)-4-hydroxy-pyrrolidin-1...)
Affinity DataIC50: 172nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776351BDBM776351([(3R)-3-(3,4-difluorophenyl)pyrrolidin-1-yl]-(3-py...)
Affinity DataIC50: 183nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776355BDBM776355([3-(4-bromophenyl)-4-methyl-pyrrolidin-1-yl]-(3-py...)
Affinity DataIC50: 188nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776313BDBM776313([3-(4-chlorophenyl)pyrrolidin-1-yl]-(3-pyridazin-4...)
Affinity DataIC50: 191nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776335BDBM776335([(3R)-3-(4-chlorophenyl)pyrrolidin-1-yl]-[3-(4-pyr...)
Affinity DataIC50: 194nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776318BDBM776318({3-(5-chloro-2-thienyl)pyrrolidin-1-yl]-[3-(4-pyri...)
Affinity DataIC50: 194nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776377BDBM776377([(3R,4S)-3-(4-chlorophenyl)-4-[(1R)-1-hydroxyethyl...)
Affinity DataIC50: 196nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776379BDBM776379([(3S)-3-(4-chloro-2-thienyl)pyrrolidin-1-yl]-(3-py...)
Affinity DataIC50: 214nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1 [28-724](Human)
F. Hoffmann-La Roche

WIPO
LigandChemical structure of BindingDB Monomer ID 776376BDBM776376([(3R,4S)-3-(4-chlorophenyl)-4-[(1S)-1-hydroxyethyl...)
Affinity DataIC50: 217nMAssay Description:Enzymatic reactions were ran in a 10µL volume consisting of 8nM human SARM1 (aa28-724), 100µM Nicotinamide (NMN) and 30µM Nicotinamide Adenine Dincul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/24/2026
Entry Details
WIPO WO2025045746

TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660068BDBM50660068(CHEMBL6160306)
Affinity DataIC50: 218nMAssay Description:Inhibition of human SARM1 expressed in human SH-SY5Y cells assessed as SARM1 P1a activity measured after 60 mins by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Rattus norvegicus)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660069BDBM50660069(CHEMBL6162644)
Affinity DataIC50: 226nMAssay Description:Inhibition of rat SARM1 extracted from HEK293 cell lysate in presence of NAD by biochemical (Fluorescence Readout) assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNAD(+) hydrolase SARM1(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50660066BDBM50660066(CHEMBL6164337)
Affinity DataIC50: 227nMAssay Description:Inhibition of human SARM1 expressed in human SH-SY5Y cells assessed as SARM1 P1a activity measured after 60 mins by cellular assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
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