Report error Found 4488 Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M2'
Affinity DataEC50: 32nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 250nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 63nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 7.90nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:NIH-3T3 cells were grown in 96-well tissue culture plates to 70% to 80% confluence. Cells were transfected with plasmid DNAs using Superfect Reagent ...More data for this Ligand-Target Pair
Affinity DataEC50: 4.89E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
Affinity DataEC50: 9.24E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
Affinity DataEC50: 2.80E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
Affinity DataEC50: 9.57E+4nMAssay Description:Assay Provider: P. Jeffrey Conn Assay Provider Affiliation: Vanderbilt University Grant Title: Discovery of novel allosteric modulators of the M1 mus...More data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Displacement of [3H]QNB from rat brain stem muscarinic receptor 2 (M2)More data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:In vitro functional agonism against M2 muscarinic receptor (cAMP)More data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
Affinity DataEC50: 69nMAssay Description:Allosteric inhibition of [3H]NMS (N-methyl-scopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
Affinity DataEC50: 9nMAssay Description:Stimulation of cAMP in CHO cells expressing human m2 receptorMore data for this Ligand-Target Pair
Affinity DataKd: 2.70nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
Affinity DataEC50: 840nMAssay Description:M2 agonist activity estimated by depression of isolated guinea pig left atriumMore data for this Ligand-Target Pair
Affinity DataKd: 41nMAssay Description:In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueMore data for this Ligand-Target Pair
Affinity DataKd: 0.430nMAssay Description:In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueMore data for this Ligand-Target Pair
Affinity DataKd: 0.200nMAssay Description:In vitro binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]-QNB as radioligand from rat heart tissueMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataEC50: 43nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
Affinity DataEC50: 74nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
Affinity DataEC50: 19nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
Affinity DataEC50: 41nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
Affinity DataEC50: 6.70nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
Affinity DataEC50: 6.10E+4nMAssay Description:Reversal of forskolin-stimulated accumulation of adenylate cyclase in transfected CHO cells, against Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
Affinity DataEC50: 2.67E+4nMAssay Description:Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsMore data for this Ligand-Target Pair
