Compile Data Set for Download or QSAR
Report error Found 5908 Enz. Inhib. hit(s) with Target = 'Monoglyceride lipase'
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26141((6-fluoropyridin-3-yl)boranediol | (6-fluoropyridi...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26142((2-phenylethyl)boranediol | Alkylboronic Acid, 21)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26123(ethyl 3-(dihydroxyboranyl)benzoate | Phenylboronic...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26125(3-(dihydroxyboranyl)benzonitrile | Phenylboronic A...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26127((3-methoxyphenyl)boranediol | Phenylboronic Acid, ...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26128((4-fluorophenyl)boranediol | CHEMBL344890 | Phenyl...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26130((4-nitrophenyl)boranediol | Phenylboronic Acid, 9)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26131(4-(dihydroxyboranyl)benzonitrile | Phenylboronic A...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26135((2-fluorophenyl)boranediol | Phenylboronic Acid, 1...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26136([2-(trifluoromethyl)phenyl]boranediol | Phenylboro...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26137((2-phenylphenyl)boranediol | Phenylboronic acid, 2...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26138((2-methoxyphenyl)boranediol | Phenylboronic Acid, ...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM150300(US8987247, 1)
Affinity DataKd:  1.40nMAssay Description:The ThermoFluor (TF) assay is a 384-well microplate-based binding assay that measures thermal stability of proteins1,2. The experiments were carried ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2015
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50461664(CHEMBL4228446)
Affinity DataEC50:  2.80E+3nMAssay Description:Activation of recombinant human MAGL using 7-HRA as substrate preincubated for 60 mins followed by substrate addition by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50461664(CHEMBL4228446)
Affinity DataEC50:  5.76E+3nMAssay Description:Activation of MAGL in mouse B16-F10 cells using 7-HRA as substrate preincubated for 60 mins followed by substrate addition measured every 2.5 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50569386(CHEMBL1356127)
Affinity DataKd:  710nMAssay Description:Binding affinity to MAGL (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50567001(CHEMBL4873898)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to human His-tagged MAGL assessed as dissociation constant by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624860(CHEMBL5434963)
Affinity DataKd:  24nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM631219(US11802133, Example 75)
Affinity DataKd:  5.70nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624852(CHEMBL5406688)
Affinity DataKd:  57nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50569655(CHEMBL4869836 | US11802133, Example 279)
Affinity DataKd:  6.10nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624853(CHEMBL5420333)
Affinity DataKd:  15nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM631260(US11802133, Example 139)
Affinity DataKd:  30nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624854(CHEMBL5400280)
Affinity DataKd:  29nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624855(CHEMBL5402965)
Affinity DataKd:  41nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624856(CHEMBL5438424)
Affinity DataKd:  30nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50624859(CHEMBL5434749)
Affinity DataKd:  27nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM640384((S)-(2-Chloro-6-fluorophenyl)(3-(3,5-difluoropheny...)
Affinity DataIC50: 0.00200nMAssay Description:The assay consists of combining endogenously expressed MGL from HeLa cells with test compounds, adding [glycerol-1,3-3H]-oleyl glycerol, incubating f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50582221(CHEMBL5090028 | US11708359, Example 60 | US1197498...)
Affinity DataIC50: 0.00700nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2024
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50582221(CHEMBL5090028 | US11708359, Example 60 | US1197498...)
Affinity DataIC50: 0.00700nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50582221(CHEMBL5090028 | US11708359, Example 60 | US1197498...)
Affinity DataIC50: 0.00720nMAssay Description:Inhibition of human MGL expressed in human HeLa cells assessed as amount of cleaved glycerol measured after 1 hrs by flow through assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50582221(CHEMBL5090028 | US11708359, Example 60 | US1197498...)
Affinity DataIC50: 0.00720nMAssay Description:Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM581474(US11505546, Example 2 | (2s,4s)-2-(2-(3-(tert-Buty...)
Affinity DataIC50: 0.0140nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM609871(US11708359, Example 62 | (rac)-(2s,4s)-2-(6-(4-(te...)
Affinity DataIC50: 0.0190nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2024
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM609871(US11708359, Example 62 | (rac)-(2s,4s)-2-(6-(4-(te...)
Affinity DataIC50: 0.0190nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM609871(US11708359, Example 62 | (rac)-(2s,4s)-2-(6-(4-(te...)
Affinity DataIC50: 0.0190nMAssay Description:Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50582222(CHEMBL5074982 | US11708359, Example 71 | US1197498...)
Affinity DataIC50: 0.0240nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2024
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50582222(CHEMBL5074982 | US11708359, Example 71 | US1197498...)
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of human MGL expressed in human HeLa cells assessed as amount of cleaved glycerol measured after 1 hrs by flow through assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50582222(CHEMBL5074982 | US11708359, Example 71 | US1197498...)
Affinity DataIC50: 0.0240nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50582222(CHEMBL5074982 | US11708359, Example 71 | US1197498...)
Affinity DataIC50: 0.0240nMAssay Description:Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM581599(US11505546, Example 14 | (2r,4s)-2-(2-(5-(tert-But...)
Affinity DataIC50: 0.0270nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50552710(CHEMBL4749516)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM609880(US11708359, Example 69 | (rac)-(2s,4s)-2-(6-(4-(1-...)
Affinity DataIC50: 0.0340nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2024
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM609880(US11708359, Example 69 | (rac)-(2s,4s)-2-(6-(4-(1-...)
Affinity DataIC50: 0.0340nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM609880(US11708359, Example 69 | (rac)-(2s,4s)-2-(6-(4-(1-...)
Affinity DataIC50: 0.0340nMAssay Description:Inhibition of MGL activity in human HeLa cells assessed as reduction in cleaved [1,3-3H glycerol] level using [glycerol-1,3-3H]-oleoyl glycerol as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM581624(US11505546, Example 39 | (rac)-(2s,4s)-2-(2-(4-(Tr...)
Affinity DataIC50: 0.0390nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50552709(CHEMBL4759880)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM50552711(CHEMBL4785835)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of MAGL (unknown origin) using 2-AG as substrate incubated for 15 mins followed by substrate addition and measured after 30 mins by mass s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM581678((2s,4S)-N-((1s,3S)-3-(4-Isopropylphenyl)cyclobutyl...)
Affinity DataIC50: 0.0400nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
Go to US Patent

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