Compile Data Set for Download or QSAR
Report error Found 81 Enz. Inhib. hit(s) with Target = 'Methylcytosine dioxygenase TET2'
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683020(US20240208998, Example 6)
Affinity DataKd:  5.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683028(US20240208998, Example 14)
Affinity DataKd:  1.40E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683027(US20240208998, Example 13)
Affinity DataKd:  1.40E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683026(US20240208998, Example 12)
Affinity DataKd:  6.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683025(US20240208998, Example 11)
Affinity DataKd:  2.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683024(US20240208998, Example 10)
Affinity DataKd:  1.10E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683023(US20240208998, Example 9)
Affinity DataKd:  9.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683022(US20240208998, Example 8)
Affinity DataKd:  1.00E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683021(US20240208998, Example 7)
Affinity DataKd:  5.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683029(US20240208998, Example 15)
Affinity DataKd:  1.10E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683019(US20240208998, Example 5)
Affinity DataKd:  2.10E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683018(US20240208998, Example 4)
Affinity DataKd:  1.20E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683017(US20240208998, Example 3)
Affinity DataKd:  1.60E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683016(US20240208998, Example 2)
Affinity DataKd:  1.50E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683015(US20240208998, Example 1)
Affinity DataKd:  1.60E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50620917(CHEMBL5415330)
Affinity DataEC50:  1.31E+5nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG tagged human TET2 catalytic domain (1129 to 2002 residues) expressed in human U2OS cells as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50620916(CHEMBL92309 | N-Methoxycarbonylmethyl-Oxalamic Aci...)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG tagged human TET2 catalytic domain (1129 to 2002 residues) expressed in human U2OS cells as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataEC50:  6.90E+3nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG tagged human TET2 catalytic domain (1129 to 2002 residues) expressed in human U2OS cells as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683034(US20240208998, Example 20)
Affinity DataKd:  5.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683042(US20240208998, Example 28)
Affinity DataKd:  6.70E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683041(US20240208998, Example 27)
Affinity DataKd:  2.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683040(US20240208998, Example 26)
Affinity DataKd:  1.60E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683039(US20240208998, Example 25)
Affinity DataKd:  1.30E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683038(US20240208998, Example 24)
Affinity DataKd:  1.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683037(US20240208998, Example 23)
Affinity DataKd:  1.50E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683036(US20240208998, Example 22)
Affinity DataKd:  2.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683035(US20240208998, Example 21)
Affinity DataKd:  7.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683033(US20240208998, Example 19)
Affinity DataKd:  1.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50570892(CHEMBL4870693)
Affinity DataKd:  3.42E+3nMAssay Description:Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50570893(CHEMBL4851104)
Affinity DataKd:  300nMAssay Description:Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50570894(CHEMBL4855677)
Affinity DataKd:  610nMAssay Description:Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50570895(CHEMBL4859276)
Affinity DataKd:  2.05E+3nMAssay Description:Binding affinity to human recombinant TET2 (1099 to 1936) catalytic domain assessed as dissociation constant by micro-scale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683032(US20240208998, Example 18)
Affinity DataKd:  5.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683031(US20240208998, Example 17)
Affinity DataKd:  1.10E+4nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM683030(US20240208998, Example 16)
Affinity DataKd:  7.00E+3nMAssay Description:The binding of compounds of the examples was determined by Surface Plasmon Resonance (SPR) using a Biacore T200 SPR biosensor instrument (GE Healthca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
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TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50570891(CHEMBL4872206)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of TET2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50590161(CHEMBL5193408)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of N-terminal His6-tagged TET2 (unknown origin) expressed in Escherichia coli assessed as reduction in hmC and fC levels preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50: 2.27E+3nMAssay Description:Inhibition of N-terminal His6-tagged TET2 (unknown origin) expressed in Escherichia coli assessed as reduction in hmC and fC levels preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50590162(CHEMBL5205660)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged TET2 (unknown origin) expressed in Escherichia coli assessed as reduction in hmC and fC levels preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of His10-FLAG tagged human TET2 catalytic domain (Q969 to I2002 residues) expressed in Sf9 cells using 5-methylcytosine as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of His10-FLAG tagged human TET2 catalytic domain (Q969 to I2002 residues) expressed in Sf9 cells using 5-methylcytosine as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50570893(CHEMBL4851104)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50570898(CHEMBL4860506)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50570897(CHEMBL4872110)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of N-terminal His6-tagged TET2 (unknown origin) expressed in Escherichia coli assessed as reduction in 5-methylcytosine oxidation by measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50344962((2S)-2-HYDROXYPENTANEDIOIC ACID | L-2-Hydroxygluta...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of His10-FLAG tagged human TET2 catalytic domain (Q969 to I2002 residues) expressed in Sf9 cells using 5-methylcytosine as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of His10-FLAG tagged human TET2 catalytic domain (Q969 to I2002 residues) expressed in Sf9 cells using 5-methylcytosine as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM50590161(CHEMBL5193408)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of N-terminal His6-tagged TET2 (unknown origin) expressed in Escherichia coli assessed as reduction in 5-methylcytosine oxidation preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM118338(US8653111, 62)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of His10-FLAG tagged human TET2 catalytic domain (Q969 to I2002 residues) expressed in Sf9 cells using 5-methylcytosine as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET2(Human)
University of Barcelona

US Patent
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataIC50: 1.97E+4nMAssay Description:Inhibition of recombinant human GST-tagged TET2 (1099 to 1936 residues) expressed in Escherichia coli BL21 (DE3)pLysS assessed as reduction in 5hmc l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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