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Report error Found 32 Enz. Inhib. hit(s) with Target = 'Methylcytosine dioxygenase TET1'
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50510129(CHEMBL4475458)
Affinity DataEC50:  2.40E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM118338(US8653111, 62)
Affinity DataEC50:  7.90E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50504654(CHEBI:76004 | AZL 0 211089 | AZL O 211089 | AZL-02...)
Affinity DataEC50:  3.16E+5nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50498665(CHEMBL1982368)
Affinity DataEC50:  440nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50620916(CHEMBL92309 | N-Methoxycarbonylmethyl-Oxalamic Aci...)
Affinity DataEC50:  1.10E+5nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50483927(CHEMBL3183531)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of tetracyclin/Dox-inducible N-terminal 3xFLAG/C-terminal GFP tagged human TET1 catalytic domain (1481 to 2136 residues) expressed in huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50570893(CHEMBL4851104)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human N-terminal Flag-tagged TET1 (1418 to 2136 residues) expressed in Baculovirus infected Sf9 cells assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50570891(CHEMBL4872206)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of TET1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50594525(CHEMBL5189434)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50594530(CHEMBL5181110)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50594527(CHEMBL5177921)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50594520(CHEMBL5194845)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26106(CHEMBL90852 | Oxalylglycine | [(carboxymethyl)carb...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM118338(US8653111, 62)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50594529(CHEMBL5201158)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50594528(CHEMBL5178563)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50508775(CHEMBL4457636)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of TET1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50508775(CHEMBL4457636)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged TET1 (1418 to 2136 residues) expressed in baculovirus infected sf9 cells assessed as reduction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50594523(CHEMBL5182454)
Affinity DataIC50: 8.10E+4nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM293660(3-({[(1S)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahyd...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM60875(GSK-J1 | 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50594531(CHEMBL5198555)
Affinity DataIC50: 1.07E+5nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26121(Succinic acid, 6 | butanedioic acid | Succinate | ...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26122(FUMARIC ACID | Fumarate | (2E)-but-2-enedioic acid...)
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosine as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50594521(CHEMBL5193964)
Affinity DataIC50: 1.66E+5nMAssay Description:Inhibition of GST-tagged human TET1 (583 to 633 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Mus musculus)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataIC50: 4.00E+6nMAssay Description:Inhibition of recombinant mouse TET1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50361471(CHEMBL1614745)
Affinity DataKi:  2.46E+5nMAssay Description:Competitive inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMethylcytosine dioxygenase TET1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50344962((2S)-2-HYDROXYPENTANEDIOIC ACID | L-2-Hydroxygluta...)
Affinity DataKi:  2.69E+5nMAssay Description:Competitive inhibition of N-terminal 3xFlag-tagged human TET1 catalytic domain (E1418 to V2136 residues) expressed in Sf9 cells using 5-methylcytosin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed