Compile Data Set for Download or QSAR
Report error Found 551 Enz. Inhib. hit(s) with Target = 'Methionine--tRNA ligase'
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553183(CHEMBL4791458)
Affinity DataEC50:  42nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553184(CHEMBL4781504)
Affinity DataEC50:  290nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553185(CHEMBL4742903)
Affinity DataEC50:  430nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553186(CHEMBL4777699)
Affinity DataEC50:  175nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553187(CHEMBL4761163)
Affinity DataEC50:  195nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553188(CHEMBL4757779)
Affinity DataEC50:  39nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553189(CHEMBL4762630)
Affinity DataEC50:  75nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553190(CHEMBL4740481)
Affinity DataEC50:  507nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553191(CHEMBL4745092)
Affinity DataEC50:  478nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553192(CHEMBL4750041)
Affinity DataEC50:  1.75E+3nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50553193(CHEMBL4795266)
Affinity DataEC50:  316nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase, mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM23447(Chloromycetin | 2,2-dichloro-N-[(1R,2R)-1,3-dihydr...)
Affinity DataEC50:  7.90E+3nMAssay Description:Inhibition of mitochondrial MetRS-mediated mitochondrial protein synthesis in human HepG2 cells measured after 6 days by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
Affinity DataKd:  450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50636199(CHEMBL5542607)
Affinity DataKd:  0.452nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
Affinity DataKd:  4.19E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Enterococcus faecalis)
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
Affinity DataKd:  300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Enterococcus faecalis)
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50636199(CHEMBL5542607)
Affinity DataKd:  150nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Enterococcus faecalis)
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Enterococcus faecalis)
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50636199(CHEMBL5542607)
Affinity DataKd:  2.70E+3nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
Affinity DataKd:  10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50636199(CHEMBL5542607)
Affinity DataKd:  4.90nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
Affinity DataKd:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50636199(CHEMBL5542607)
Affinity DataKd:  1.40nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
Affinity DataKd:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50636199(CHEMBL5542607)
Affinity DataKd:  0.493nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
Affinity DataKd:  0.593nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
Affinity DataKd:  1.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain Mu50 / ATCC 700699))
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50170723(N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(im...)
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  6.54E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  81nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMethionine--tRNA ligase, cytoplasmic(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50112575(2-[3-(6,8-Dibromo-1,2,3,4-tetrahydro-quinolin-4-yl...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory concentration against Methionyl-tRNA synthetase in a pyrophosphate exchange assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124821(2-[3-(3,5-Dichloro-benzylamino)-propylamino]-1H-qu...)
Affinity DataIC50: 3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222704(CHEMBL345835)
Affinity DataIC50: 3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222701(CHEMBL158051)
Affinity DataIC50: 3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222699(CHEMBL161300)
Affinity DataIC50: 3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222700(CHEMBL161864)
Affinity DataIC50: 3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222703(CHEMBL160841)
Affinity DataIC50: 3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222702(CHEMBL161347)
Affinity DataIC50: 3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222705(CHEMBL161312)
Affinity DataIC50: 3nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124843(2-[3-(3-Bromo-2-ethoxy-5-methoxy-benzylamino)-prop...)
Affinity DataIC50: 3.10nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124811(2-[3-(3-Bromo-5-iodo-benzylamino)-propylamino]-1H-...)
Affinity DataIC50: 3.20nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124826(2-[3-(2-Ethoxy-5-iodo-3-methyl-benzylamino)-propyl...)
Affinity DataIC50: 3.20nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124808(2-[3-(2-Ethoxy-3-iodo-5-methoxy-benzylamino)-propy...)
Affinity DataIC50: 3.30nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain MW2))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149651(2-[3-(3-Bromo-2-ethoxy-5-methoxy-benzylamino)-prop...)
Affinity DataIC50: 3.30nMAssay Description:Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124846(2-[3-(5,7-Dichloro-1,2,3,4-tetrahydro-naphthalen-1...)
Affinity DataIC50: 3.80nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain MW2))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149623(N-(1H-Benzoimidazol-2-yl)-N''-(3-bromo-5-chloro-2-...)
Affinity DataIC50: 3.80nMAssay Description:Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124851(4-Ethoxy-3-methyl-5-{[3-(4-oxo-1,4-dihydro-quinoli...)
Affinity DataIC50: 3.90nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain MW2))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149650(2-[3-(3,5-Dibromo-benzylamino)-propylamino]-1H-thi...)
Affinity DataIC50: 3.90nMAssay Description:Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50124803(5-Bromo-2-ethoxy-3-{[3-(4-oxo-1,4-dihydro-quinolin...)
Affinity DataIC50: 4nMAssay Description:Compound tested for inhibition of Staphylococcus aureus MRS (methionyl tRNA synthetase) in aminoacylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMethionine--tRNA ligase(Staphylococcus aureus (strain MW2))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149646(5-[3-(3,5-Dibromo-benzylamino)-propylamino]-4H-thi...)
Affinity DataIC50: 4nMAssay Description:Inhibitory concentration against Staphylococcus aureus methionyl tRNA synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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