Compile Data Set for Download or QSAR
Report error Found 1940 Enz. Inhib. hit(s) with Target = 'Leukotriene A-4 hydrolase'
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303649(4-{(S)-2-[4-(4-Chlorophenoxy)phenoxymethyl]pyrroli...)
Affinity DataKd:  25nMAssay Description:Binding affinity to human recombinant LTA4H by isothermal calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50197084(CHEMBL3883608)
Affinity DataKd:  220nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50197084(CHEMBL3883608)
Affinity DataKd:  130nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50197085(CHEMBL3921982)
Affinity DataKd:  60nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKd:  6.25E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataKd:  350nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50197085(CHEMBL3921982)
Affinity DataKd:  270nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataKd:  60nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKd:  6.37E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50197084(CHEMBL3883608)
Affinity DataKd:  310nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataKd:  5.15E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKd:  8.47E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50197085(CHEMBL3921982)
Affinity DataKd:  270nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataKd:  4.63E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM23971(CHEMBL29292 | (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-...)
Affinity DataKd:  2.05E+3nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50116538(SC-57461A | CHEMBL543405 | CHEMBL112671 | 3-{[3-(4...)
Affinity DataKd:  290nMAssay Description:Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50197084(CHEMBL3883608)
Affinity DataEC50:  240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50639734(CHEMBL5567961)
Affinity DataEC50:  420nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50639735(CHEMBL5564507)
Affinity DataEC50:  50nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50639736(CHEMBL5562304)
Affinity DataEC50:  120nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50639737(CHEMBL5556155)
Affinity DataEC50:  120nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50639738(CHEMBL5568126)
Affinity DataEC50:  1.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50639739(CHEMBL5564496)
Affinity DataEC50:  2.04E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50639740(CHEMBL5567545)
Affinity DataEC50:  1.42E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.42E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326921(4-(1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl...)
Affinity DataIC50: 0.0420nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326921(4-(1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl...)
Affinity DataIC50: 0.0420nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326945(1-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50: 0.0700nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326945(1-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50: 0.0700nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327137(4-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50: 0.0800nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327137(4-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50: 0.0800nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327181(1-{(1S,4S)-5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,...)
Affinity DataIC50: 0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327189(5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyridin...)
Affinity DataIC50: 0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326957(N-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50: 0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327016((3S)-3-{4-[(1s,4s)-7- azabicyclo[2.2.1]hept-7- y...)
Affinity DataIC50: 0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327016((3S)-3-{4-[(1s,4s)-7- azabicyclo[2.2.1]hept-7- y...)
Affinity DataIC50: 0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326957(N-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50: 0.0900nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327151(7-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...)
Affinity DataIC50: 0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326947(1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...)
Affinity DataIC50: 0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326992((3S)-3-[4-(azepan-1- ylmethyl)phenyl]-2,3- dihyd...)
Affinity DataIC50: 0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327040(4-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50: 0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326947(1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...)
Affinity DataIC50: 0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327151(7-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2-yl]benz...)
Affinity DataIC50: 0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326992((3S)-3-[4-(azepan-1- ylmethyl)phenyl]-2,3- dihyd...)
Affinity DataIC50: 0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327040(4-(1-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]py...)
Affinity DataIC50: 0.100nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327185((1S,4S)-5-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b...)
Affinity DataIC50: 0.110nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326933([(3R)-1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- ...)
Affinity DataIC50: 0.110nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326933([(3R)-1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- ...)
Affinity DataIC50: 0.110nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM327156((1-{4-[(2S)-2,3-dihydro-1,4- benzodioxin-2- yl]b...)
Affinity DataIC50: 0.120nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetLeukotriene A-4 hydrolase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM326944(7-{4-[(3S)-2,3- dihydro[1,4]dioxino[2,3- b]pyrid...)
Affinity DataIC50: 0.120nMAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

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