Compile Data Set for Download or QSAR
Report error Found 985 Enz. Inhib. hit(s) with Target = 'Ketohexokinase'
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241201(CHEMBL4074975)
Affinity DataKd:  1.03E+5nMAssay Description:Binding affinity to full length recombinant human biotin-labeled KHK by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241205(CHEMBL1463512)
Affinity DataKd:  4.40E+4nMAssay Description:Binding affinity to full length recombinant human biotin-labeled KHK by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMed
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241206(CHEMBL1500542)
Affinity DataKd:  6.20E+4nMAssay Description:Binding affinity to full length recombinant human biotin-labeled KHK by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241207(CHEMBL4086173)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to full length recombinant human biotin-labeled KHK by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241206(CHEMBL1500542)
Affinity DataKd:  6.20E+4nMAssay Description:Binding affinity to recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50241205(CHEMBL1463512)
Affinity DataKd:  4.40E+4nMAssay Description:Binding affinity to recombinant His-tagged human KHK expressed in Escherichia coli in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM655985(US20240067633, Isomer 2 of compound 3)
Affinity DataEC50:  37.4nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase Isoform A(Human)
Sichuan Haisco Pharmaceutical Co.

US Patent
LigandPNGBDBM655985(US20240067633, Isomer 2 of compound 3)
Affinity DataEC50:  51.8nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Mouse)
Sichuan Haisco Pharmaceutical Co.

US Patent
LigandPNGBDBM655985(US20240067633, Isomer 2 of compound 3)
Affinity DataEC50:  134nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Rat)
Sichuan Haisco Pharmaceutical Co.

US Patent
LigandPNGBDBM655985(US20240067633, Isomer 2 of compound 3)
Affinity DataEC50:  146nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM655986(US20240067633, Isomer 2 of compound 4)
Affinity DataEC50:  19.4nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM655987((S)-2-(1-(4-cyano-5,5-difluoro-3-(2-methylazetidin...)
Affinity DataEC50:  36.5nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase Isoform A(Human)
Sichuan Haisco Pharmaceutical Co.

US Patent
LigandPNGBDBM655987((S)-2-(1-(4-cyano-5,5-difluoro-3-(2-methylazetidin...)
Affinity DataEC50:  35.2nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM655988(US20240067633, Isomer 1 of compound 8)
Affinity DataEC50:  58.6nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase Isoform A(Human)
Sichuan Haisco Pharmaceutical Co.

US Patent
LigandPNGBDBM655988(US20240067633, Isomer 1 of compound 8)
Affinity DataEC50:  59.7nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM655989(2-((1R,5S,6R)-3-(7,7-difluoro-2-((S)-2-(methyl-d3)...)
Affinity DataEC50:  37.7nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM655990((S)-2-(1-(4-cyano-5,5-difluoro-3-(2-(methyl-d3)aze...)
Affinity DataEC50:  52.7nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM655991(US20240067633, Isomer 2 of compound 19)
Affinity DataEC50:  60.6nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM655992(US20240067633, Isomer 2 of compound 20)
Affinity DataEC50:  49.8nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM655993(US20240067633, Compound Control)
Affinity DataEC50:  123nMAssay Description:Experiment of Inhibitory Activity Against KHK In Vitro: With the involvement of ATP, fructokinase phosphorylates fructose to produce fructose-1-phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM738719(2-((1R,5S,6R)-3-(5-cyano-6-((S)- 2-methylazetidine...)
Affinity DataIC50: 0.170nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM738731(Preparation of 2-((1R,5S,6R)-3-(5-cyano-6-((S)-2-m...)
Affinity DataIC50: 0.390nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM738730(Preparation of 2-((1R,5S,6R)-3-(5-cyano-6-((S)-2-m...)
Affinity DataIC50: 0.440nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50628740(CHEMBL5402865)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KHK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM749704(acid | US12331038, Compound 2)
Affinity DataIC50: 0.520nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50648642(CHEMBL5611924)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM749706(US12331038, Compound 3-1)
Affinity DataIC50: 0.730nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM749705(acid | US12331038, Compound 1)
Affinity DataIC50: 0.820nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM707376((2S,3R)-1-{5-chloro-4-[1-(1- methyl-3-azetidinyl)-...)
Affinity DataIC50: 0.856nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM749709(US12331038, Compound 6-1)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 1nMAssay Description:Inhibition of 1 nM recombinant human N-terminal His-tagged KHKC expressed in Escherichia coli BL21 (DE3) using fructose as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM707378((2S,3R)-2-methyl-1-{5-methyl-4- [1-(1-methyl-3-aze...)
Affinity DataIC50: 1.05nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Rat)
Sichuan Haisco Pharmaceutical Co.

US Patent
LigandPNGBDBM707376((2S,3R)-1-{5-chloro-4-[1-(1- methyl-3-azetidinyl)-...)
Affinity DataIC50: 1.10nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM511679(US11083720, Compound C-1 | 4-(1-phenyl-1H-indazol-...)
Affinity DataIC50: 1.17nMAssay Description:Specific high-throughput screening assays were developed for KHK-C and KHK-A using recombinant proteins. Purified human recombinant KHK-C and KHK-A w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50648638(CHEMBL5613941)
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 1.5nMAssay Description:Compounds having an IC50 value less than 20 nM were examined in a second KHK assay, referred to as Assay B, using 10-fold less enzyme and measuring a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)
Affinity DataIC50: 1.5nMAssay Description:Compounds having an IC50 value less than 20 nM were examined in a second KHK assay, referred to as Assay B, using 10-fold less enzyme and measuring a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319605([(1R,5S,6R)-3-{5-cyano-4-(1,1-difluoroethyl)-3-flu...)
Affinity DataIC50: 1.5nMAssay Description:Compounds having an IC50 value less than 20 nM were examined in a second KHK assay, referred to as Assay B, using 10-fold less enzyme and measuring a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM464138([(1R,5S,6R)-3-{5-cyano-4-(1,1-difluoroethyl)-3-flu...)
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM494884(US10988463, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50: 1.5nMAssay Description:Assay B, using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 1.5nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319583(US10174007, Example 2 | US10787438, Example 2 | US...)
Affinity DataIC50: 1.5nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM601403(US11634410, Example 50 | [(1R,5S,6R)-3-{5-cyano-4-...)
Affinity DataIC50: 1.5nMAssay Description:Using 10-fold less enzyme and measuring absorbance for 3 hours to obtain IC50 values below the 10 nM lower limit of Assay A. Compounds were prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM707387((2S,3R)-1-{6-(difluoromethyl)-5- methyl-4-[1-(1-me...)
Affinity DataIC50: 1.5nMAssay Description:Determination of Human and Rat recombinant KHK-A and KHK-C isozyme IC50 ValuesAn assay reagent cocktail was prepared by combining NADH, water, TEA, K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/23/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM319582(US10174007, Example 1 | US10787438, Example 1 | US...)
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

TargetKetohexokinase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM749708(US12331038, Compound 4-2)
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/9/2025
Entry Details
Go to US Patent

Displayed 1 to 50 (of 985 total ) | Next | Last >>
Jump to: