Compile Data Set for Download or QSAR
Report error Found 690 Enz. Inhib. hit(s) with Target = 'Integrin alpha-5/beta-1'
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50139204(3-[4-(3-Guanidino-benzoylamino)-phenylsulfanyl]-3-...)
Affinity DataEC50: >1.00E+5nMAssay Description:K562 cell adhesion via integrin alpha5-beta1 to fibrinogenMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50021393(CHEMBL3289604)
Affinity DataEC50:  12nMAssay Description:Agonist activity at alpha5beta1 integrin in human K562 cells assessed as increase of fibronectin-mediated cell adhesion after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50021394(CHEMBL3289605)
Affinity DataEC50:  763nMAssay Description:Agonist activity at alpha5beta1 integrin in human K562 cells assessed as increase of fibronectin-mediated cell adhesion after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50021395(CHEMBL3289606)
Affinity DataEC50:  365nMAssay Description:Agonist activity at alpha5beta1 integrin in human K562 cells assessed as increase of fibronectin-mediated cell adhesion after 30 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKd:  100nMAssay Description:Binding affinity to human integrin alpha5beta1 after 6 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKd:  0.257nMAssay Description:Binding affinity to human integrin alpha8beta1 by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKd:  0.260nMAssay Description:Binding affinity to human integrin alpha8beta1 by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50464108(CHEMBL4241824)
Affinity DataKd:  100nMAssay Description:Binding affinity to human integrin alpha5beta1 after 6 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50021395(CHEMBL3289606)
Affinity DataEC50:  365nMAssay Description:Agonist activity at alpha5beta1 integrin receptor in human K562 cells assessed as increase in fibronectin-induced cell adhesion pre-incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50505775(CHEMBL4442651)
Affinity DataEC50:  140nMAssay Description:Agonist activity at alpha5beta1 integrin receptor in human K562 cells assessed as increase in fibronectin-induced cell adhesion pre-incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50505779(CHEMBL4461771)
Affinity DataEC50:  1.03E+3nMAssay Description:Agonist activity at alpha5beta1 integrin receptor in human K562 cells assessed as increase in fibronectin-induced cell adhesion pre-incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50505782(CHEMBL4586928)
Affinity DataEC50:  9.90nMAssay Description:Agonist activity at alpha5beta1 integrin receptor in human K562 cells assessed as increase in fibronectin-induced cell adhesion pre-incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50021393(CHEMBL3289604)
Affinity DataEC50:  12nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50021394(CHEMBL3289605)
Affinity DataEC50:  763nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50021395(CHEMBL3289606)
Affinity DataEC50:  365nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50550223(CHEMBL4794300)
Affinity DataEC50:  45nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50550224(CHEMBL4797755)
Affinity DataEC50:  6.70nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50505779(CHEMBL4461771)
Affinity DataEC50:  1.03E+3nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50550228(CHEMBL4743438)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50505772(CHEMBL4589062)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50505782(CHEMBL4586928)
Affinity DataEC50:  9.90nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataEC50:  49nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50222360(Ac-Asp-Arg-Leu-Asp-Ser-OH | CHEMBL238484)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50313793((S)-3-(3-amino-4-(3-(5,6,7,8-tetrahydro-1,8-naphth...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Integrin alpha5beta3 receptors expressed in HOP cells assessed as cell attachment after 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50138318((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of alpha5-beta1 integrin receptor in ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50138318((5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzen...)
Affinity DataIC50: 0.180nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50313795((S)-3-(4-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human Integrin alpha5beta3 receptors expressed in HOP cells assessed as cell attachment after 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM279568((3S)-3-[3-bromo-5-(trifluoromethyl)phenyl]-3-[[2-[...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1 [T112H](Human)
Saint Louis University

US Patent
LigandPNGBDBM279568((3S)-3-[3-bromo-5-(trifluoromethyl)phenyl]-3-[[2-[...)
Affinity DataIC50: 0.300nMAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50138313((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of alpha5-beta1 integrin receptor in ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50138313((5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-...)
Affinity DataIC50: 0.390nMAssay Description:Alpha-5 beta-1 antagonism using an ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50497721(CHEMBL3319235)
Affinity DataIC50: 0.390nMAssay Description:Antagonist activity at alpha5beta1 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM279562((3S)-3-[3-chloro-5-(difluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM279570((3S)-3-[3-bromo-5-methyl-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1 [T112H](Human)
Saint Louis University

US Patent
LigandPNGBDBM279562((3S)-3-[3-chloro-5-(difluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50: 0.5nMAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1 [T112H](Human)
Saint Louis University

US Patent
LigandPNGBDBM279570((3S)-3-[3-bromo-5-methyl-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.5nMAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50217428(2S,3R,5S-4-{[2-carboxy-2-(2,4,6-trimethyl-benzoyla...)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of integrin alpha-5-beta-1 receptor by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50217419(2S,3R,5S-3-(2-{1-(3,3-dimethyl-butyryl)-5-[(4-meth...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of integrin alpha-5-beta-1 receptor by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50217426(2S,3R,5S-3-(2-{1-(3,3-dimethyl-butyryl)-5-[(4-meth...)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of integrin alpha-5-beta-1 receptor by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM279565((3S)-3-[3-bromo-5-chloro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM279567((3S)-3-(3-bromo-5-chloro-phenyl)-3-[[2-[[5-[(5-hyd...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM279572((3S)-3-[3-bromo-5-fluoro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM279573((3S)-3-(3,5-dibromophenyl)-3-[[2-[[5-[(5-hydroxy-1...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1 [T112H](Human)
Saint Louis University

US Patent
LigandPNGBDBM279565((3S)-3-[3-bromo-5-chloro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.600nMAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1 [T112H](Human)
Saint Louis University

US Patent
LigandPNGBDBM279567((3S)-3-(3-bromo-5-chloro-phenyl)-3-[[2-[[5-[(5-hyd...)
Affinity DataIC50: 0.600nMAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1 [T112H](Human)
Saint Louis University

US Patent
LigandPNGBDBM279572((3S)-3-[3-bromo-5-fluoro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50: 0.600nMAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1 [T112H](Human)
Saint Louis University

US Patent
LigandPNGBDBM279573((3S)-3-(3,5-dibromophenyl)-3-[[2-[[5-[(5-hydroxy-1...)
Affinity DataIC50: 0.600nMAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
Go to US Patent

TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50439683(CHEMBL2418221)
Affinity DataIC50: 0.670nMAssay Description:Antagonist activity at alpha5beta1 in human K562 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibrone...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM50313794((S)-3-(3-(20-amino-3,6,9,12,15,18-hexaoxaicosanami...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human Integrin alpha5beta3 receptors expressed in HOP cells assessed as cell attachment after 30 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
Nerviano

Curated by ChEMBL
LigandPNGBDBM279563((3S)-3-[3-bromo-5-(difluoromethyl)phenyl)-3-(2-(3-...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:Purified human fibronectin (R&D Systems, 1918-FN) diluted to 2 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

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