Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Hydroxysteroid 11-beta dehydrogenase 1'
TargetHydroxysteroid 11-beta dehydrogenase 1(Rhesus macaque)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611953(CHEMBL5289716)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of monkey 11beta-HSD1 in liver microsome incubated for 24 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataIC50: 45nMAssay Description:Inhibition of dog 11beta-HSD1 expressed in CHO cells assessed as conversion of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50392216(CHEMBL2153191 | US8673938, 7)
Affinity DataIC50: 3.77E+3nMAssay Description:Inhibition of N-terminal His6-tagged full length dog 11betaHSD1 expressed in baculovirus infected cells using cortisone as substrate after 25 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50273458((S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydr...)
Affinity DataKi:  12nMAssay Description:Inhibition of dog recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed