Compile Data Set for Download or QSAR
Report error Found 110 Enz. Inhib. hit(s) with Target = 'Glutaminase kidney isoform, mitochondrial [63-669]'
TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416666(US10323028, Example 11(a) | (2S)-2-Methoxy-2-[3-me...)
Affinity DataIC50: 6.11nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416667(US10323028, Example 11(b) | (2R)-2-Methoxy-2-[3-me...)
Affinity DataIC50: 6.35nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387023((2S)-N-[5-[[(3R)-1-(5-chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50: 15.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387034(N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3...)
Affinity DataIC50: 18.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416687(US10323028, Example 21(b) | (2R)-2-(3,5-Dimethoxyp...)
Affinity DataIC50: 20nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416687(US10323028, Example 21(b) | (2R)-2-(3,5-Dimethoxyp...)
Affinity DataIC50: 20nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416638(US10323028, Example 1(a) | (2S)-2-[3-(3-Fluoroazet...)
Affinity DataIC50: 20.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416681(US10323028, Example 18(b) | (2R)-2-Methoxy-2-[3-(o...)
Affinity DataIC50: 22.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387019((2S)-2-[3-(difluoromethoxy)phenyl]-N-[5-[[(3R)-1-(...)
Affinity DataIC50: 22.7nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM492979(US10981904, Example 26 | 2-(3,5-dimethoxyphenyl)-N...)
Affinity DataIC50: 23.5nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387030(US9938265, Example 18 | N-[5-[[(3R)-1-(6-fluoropyr...)
Affinity DataIC50: 24.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416677(US10323028, Example 16(b) | (2R)-2-(3,5-Dimethoxyp...)
Affinity DataIC50: 25.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416654(US10323028, Example 6(a) | (2S)-2-(3,5-Dimethoxyph...)
Affinity DataIC50: 28nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416652(US10323028, Example 5(a) | (2R)-3-Methoxy-2-(3-met...)
Affinity DataIC50: 28.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387007((2S)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...)
Affinity DataIC50: 30.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416643(US10323028, Example 3(a) | (2S)-2-Methoxy-2-[3-(3-...)
Affinity DataIC50: 30.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387021((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(5...)
Affinity DataIC50: 31.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416664(US10323028, Example 10(a) | (2S)-2-[3-(3-Fluoroaze...)
Affinity DataIC50: 34.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387025((2S)-N-[5-[[(3R)-1-(5-Chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50: 35.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387045((2S)-N-[5-[[(3R)-1-(5-chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50: 35.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387008((2S)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...)
Affinity DataIC50: 38.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416683(US10323028, Example 19(b) | (2R)-2-Ethoxy-N-[5-[[(...)
Affinity DataIC50: 40.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416650(US10323028, Example 4(a) | (2S)-2-(3,5-Dimethoxyph...)
Affinity DataIC50: 42.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416669(US10323028, Example 12(b) | (2R)-2-Methoxy-2-[3-(3...)
Affinity DataIC50: 43.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387027((2S)-2-methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Affinity DataIC50: 44.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM492996(US10981904, Example 41 | 2-[3-(3,3-difluoroazetidi...)
Affinity DataIC50: 46.7nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416686(US10323028, Example 21(a) | (2S)-2-(3,5-Dimethoxyp...)
Affinity DataIC50: 48.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416686(US10323028, Example 21(a) | (2S)-2-(3,5-Dimethoxyp...)
Affinity DataIC50: 48.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416686(US10323028, Example 21(a) | (2S)-2-(3,5-Dimethoxyp...)
Affinity DataIC50: 48.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416679(US10323028, Example 17(b) | (2R)-[3-(Difluorometho...)
Affinity DataIC50: 50.4nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM492982(US10981904, Example 29 | 2-[3-(3,3-difluoroazetidi...)
Affinity DataIC50: 51.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416680(US10323028, Example 18(a) | (2S)-2-Methoxy-2-[3-(o...)
Affinity DataIC50: 52.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387005((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Affinity DataIC50: 55.4nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387032(US9938265, Example 20 | 2-(4-fluorophenyl)-N-[5-[[...)
Affinity DataIC50: 55.7nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416663(US10323028, Example 9(b) | (2R)-N-[5-[[(3R)-1-(6-F...)
Affinity DataIC50: 59.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387026((2S)-2-Methoxy-N-[5-[[(3R)-1-(5-methylpyridazin-3-...)
Affinity DataIC50: 59.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387044((2S)-2-methoxy-N-[5-[[(3R)-1-(5-methylpyridazin-3-...)
Affinity DataIC50: 59.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416651(US10323028, Example 4(b) | (2R)-2-(3,5-Dimethoxyph...)
Affinity DataIC50: 59.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416684(US10323028, Example 20(a) | (2S)-2-[4-Fluoro-3-(tr...)
Affinity DataIC50: 64.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416657(US10323028, Example 8(a) | (2S)-2-[4-Fluoro-3-(3-f...)
Affinity DataIC50: 64.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387030(US9938265, Example 18 | N-[5-[[(3R)-1-(6-fluoropyr...)
Affinity DataIC50: 65.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416689(US10323028, Example 22(b) | (2R)-2-ethoxy-2-[3-(3-...)
Affinity DataIC50: 68.5nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416688(US10323028, Example 22(a) | (2S)-2-ethoxy-2-[3-(3-...)
Affinity DataIC50: 68.5nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416685(US10323028, Example 20(b) | (2R)-2-[4-Fluoro-3-(tr...)
Affinity DataIC50: 69.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM387036(2-(4-fluoro-3-methoxy-phenyl)-N-[5-[[(3R)-1-(6-flu...)
Affinity DataIC50: 71.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416644(US10323028, Example 3(b) | (2R)-2-Methoxy-2-[3-(3-...)
Affinity DataIC50: 72.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM492944(US10981904, Example 10(b) | (2S)-2-[3-(3-Fluoroaze...)
Affinity DataIC50: 72.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416639(US10323028, Example 1(b) | (2R)-2-[3-(3-Fluoroazet...)
Affinity DataIC50: 72.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM416671(US10323028, Example 13(b) | (2R)-2-Methoxy-2-[3-(3...)
Affinity DataIC50: 75.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
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Date in BDB:
10/26/2021
Entry Details
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TargetGlutaminase kidney isoform, mitochondrial [63-669](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM492990(US10981904, Example 35 | 2-[3-(3-fluoroazetidin-1-...)
Affinity DataIC50: 77nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

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