Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with Target = 'Gamma-secretase-activating protein'
TargetGamma-secretase-activating protein(Human)
Memorial Sloan-Kettering Cancer Center

US Patent
LigandPNGBDBM157135(US9023767, GSI-34)
Affinity DataIC50: 1nMAssay Description:Among the advantages of this Abeta 42 HTRF gamma-secretase assay is the construction of the biotinylated, recombinant CT6-I45F substrate, which has p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetGamma-secretase-activating protein(Human)
Memorial Sloan-Kettering Cancer Center

US Patent
LigandPNGBDBM157134(US9023767, Compound E)
Affinity DataIC50: 1.20nMAssay Description:Among the advantages of this Abeta 42 HTRF gamma-secretase assay is the construction of the biotinylated, recombinant CT6-I45F substrate, which has p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2015
Entry Details
Go to US Patent

TargetGamma-secretase-activating protein(Human)
Memorial Sloan-Kettering Cancer Center

US Patent
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human gamma secretase by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed