Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with Target = 'Gamma-secretase subunit PEN-2'
TargetGamma-secretase subunit PEN-2(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50143556((S)-2-{(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]...)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against gamma-secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-secretase subunit PEN-2(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50100434(tert-butyl (2S,3R,5R)-5-(((S)-1-((S)-1-amino-1-oxo...)
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration against gamma-secretase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-secretase subunit PEN-2(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50369830(CHEMBL1790471)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-secretase subunit PEN-2(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50100435([1-(1-Formyl-butylcarbamoyl)-3-methyl-butyl]-carba...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-secretase subunit PEN-2(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetGamma-secretase subunit PEN-2(Human)
University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50100438(2-Acetylamino-4-methyl-pentanoic acid [1-(1-formyl...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Amyloid-beta production in APP-transfected cells at level of gamma secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed