Compile Data Set for Download or QSAR
Report error Found 98 Enz. Inhib. hit(s) with Target = 'Gamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1'
LigandPNGBDBM28978({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophen...)
Affinity DataEC50:  4.20nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28990(4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoropheny...)
Affinity DataEC50:  10.7nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28989(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.150nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28988(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.660nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28987(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.25nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.650nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM28985(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.820nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28984(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  4.20nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28983(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  35nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28982({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophen...)
Affinity DataEC50:  1.90nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28981(4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoropheny...)
Affinity DataEC50:  510nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28980(1-[({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoro...)
Affinity DataEC50:  0.360nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28979({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophen...)
Affinity DataEC50:  1.10nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28991((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  15nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28977(2-[({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoro...)
Affinity DataEC50:  2.10nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28976(2-{1-[(4-chlorobenzene)sulfonyl]-4-{[(2-methoxyben...)
Affinity DataEC50:  0.510nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28975(2-[({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoro...)
Affinity DataEC50:  0.650nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28974(2-{4-[(benzenesulfonyl)methyl]-1-[(4-chlorobenzene...)
Affinity DataEC50:  8.80nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28973(2-{1-[(4-chlorobenzene)sulfonyl]-4-[(trifluorometh...)
Affinity DataEC50:  21.5nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28972(2-{1-[(4-chlorobenzene)sulfonyl]-4-[(cyclopropanes...)
Affinity DataEC50:  1.40nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28971(1-({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorop...)
Affinity DataEC50:  1nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28970([({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  1.70nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28969(methyl N-({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-di...)
Affinity DataEC50:  2.20nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28968(({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophe...)
Affinity DataEC50:  1nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM28967(N-({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorop...)
Affinity DataEC50:  1.30nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM29002((3R)-3-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  4nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29013(4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[(...)
Affinity DataEC50:  0.510nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29012(N-[(4R)-4-{[5-chloro-2-(hydroxymethyl)phenyl](4-ch...)
Affinity DataEC50:  0.320nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29011((2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfo...)
Affinity DataEC50:  0.270nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29010((2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfo...)
Affinity DataEC50:  0.480nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29009((2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfo...)
Affinity DataEC50:  0.410nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29008((2R)-2-[(5-chloro-2-fluorophenyl)(4-chlorobenzene)...)
Affinity DataEC50:  0.660nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29007((2R)-2-[(4-chlorobenzene)(2,5-difluorophenyl)sulfo...)
Affinity DataEC50:  1.20nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29006((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  19nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29005((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  0.0600nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29004((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  0.0600nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29003((3R)-3-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  7.70nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28966({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophen...)
Affinity DataEC50:  0.510nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2009
Entry Details Article
PubMed
LigandPNGBDBM29001((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  0.930nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM29000((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  1.80nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28999((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  18nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28998((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  12nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28997((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  5.60nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28996((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  15nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28995((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  12nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28994((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  2.10nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28993((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  2.30nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28960(BMCL18464 Compound 14 | (2R)-2-{[5-chloro-2-(hydro...)
Affinity DataEC50:  10nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28992((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  10nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
LigandPNGBDBM28921((2S,3S)-N-(4-bromophenyl)-1-hydroxy-3-methylpentan...)
Affinity DataEC50:  2.21E+3nMAssay Description:A Chinese Hamster Ovary cell line stably expressing human beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
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