Compile Data Set for Download or QSAR
Report error Found 137 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-4'
TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50273002(5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochlor...)
Affinity DataEC50:  1.28E+5nMAssay Description:Agonist activity at rat recombinant GABAA alpha-4-beta-3-gamma-2 receptor expressed in HEK293 cells assessed as normalization of GABA-induced current...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50049736(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)
Affinity DataEC50:  3.24E+5nMAssay Description:Activity at alpha-4-beta-3-gamma-2 GABAA receptor expressed in Xenopus oocytes assessed as inhibition in GABA-induced current by voltage clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataEC50:  163nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta2delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataEC50:  60nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha4beta3 expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457445(CHEMBL4212818)
Affinity DataEC50:  970nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha4beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta(Rat)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50457439(CHEMBL4213357)
Affinity DataEC50:  150nMAssay Description:Modulation of rat eGFP-fused GABA-A receptor alpha4beta3delta expressed in HEK293 cells in presence of GABA by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50191342(3alpha-hydroxy-5alpha-pregnan-20-one | CHEMBL20753...)
Affinity DataEC50:  76nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50258253(CHEMBL4085062)
Affinity DataEC50:  744nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258248(CHEMBL4084134)
Affinity DataEC50:  577nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataEC50:  299nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258217(CHEMBL3427530)
Affinity DataEC50:  1.24E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258256(CHEMBL3427532)
Affinity DataEC50:  240nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258254(CHEMBL4073780)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258252(CHEMBL4073679)
Affinity DataEC50:  1.36E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258249(CHEMBL4080678)
Affinity DataEC50:  2.01E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258229(CHEMBL4103751)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258243(CHEMBL4081622)
Affinity DataEC50:  2.05E+3nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50258255(CHEMBL4062424)
Affinity DataEC50:  192nMAssay Description:Positive allosteric modulation of GABAA receptor alpha4beta3delta (unknown origin) expressed in CHO cells assessed as potentiation of GABA-mediated i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525187(CHEMBL4554798)
Affinity DataEC50:  8.60E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525185(CHEMBL4464494)
Affinity DataEC50:  2.60E+4nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525188(CHEMBL4526098)
Affinity DataEC50:  1.40E+4nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525189(CHEMBL4458674)
Affinity DataEC50:  7.90E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50367949(CHEMBL1788265)
Affinity DataEC50:  8.10E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50026410(CHEBI:16974 | Imidazole acetic acid)
Affinity DataEC50:  1.86E+4nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50367949(CHEMBL1788265)
Affinity DataEC50:  8.13E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525189(CHEMBL4458674)
Affinity DataEC50:  7.94E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525187(CHEMBL4554798)
Affinity DataEC50:  8.51E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525185(CHEMBL4464494)
Affinity DataEC50:  2.63E+4nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525191(CHEMBL4547372)
Affinity DataEC50:  590nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50026410(CHEBI:16974 | Imidazole acetic acid)
Affinity DataEC50:  1.90E+4nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataEC50:  3.72E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525188(CHEMBL4526098)
Affinity DataEC50:  1.41E+4nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525192(CHEMBL79325)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataEC50:  3.70E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525191(CHEMBL4547372)
Affinity DataEC50:  590nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50525192(CHEMBL79325)
Affinity DataEC50:  1.32E+3nMAssay Description:Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50457445(CHEMBL4212818)
Affinity DataEC50:  980nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587075(CHEMBL5081682)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587076(CHEMBL5090382)
Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587077(CHEMBL5069550)
Affinity DataEC50:  1.92E+3nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587078(CHEMBL5088746)
Affinity DataEC50:  140nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50587079(CHEMBL5072077)
Affinity DataEC50:  60nMAssay Description:Positive allosteric modulation of human recombinant alpha4beta1delta GABAA receptor expressed in delta-HEK cells assessed as potentiation of GABA-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM235902(US9365502, MQ-87)
Affinity DataIC50: 14nMAssay Description:The IC50 values for non-competitive displacers of [35S]-TBPS from the picrotoxin binding site on GABAA receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM235905(US9365502, MQ-85)
Affinity DataIC50: 29nMAssay Description:The IC50 values for non-competitive displacers of [35S]-TBPS from the picrotoxin binding site on GABAA receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM235901(US9365502, MQ-86)
Affinity DataIC50: 43nMAssay Description:The IC50 values for non-competitive displacers of [35S]-TBPS from the picrotoxin binding site on GABAA receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM235900(US9365502, MQ-37)
Affinity DataIC50: 46nMAssay Description:The IC50 values for non-competitive displacers of [35S]-TBPS from the picrotoxin binding site on GABAA receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM235898(US9365502, MQ-38)
Affinity DataIC50: 52nMAssay Description:The IC50 values for non-competitive displacers of [35S]-TBPS from the picrotoxin binding site on GABAA receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM235894(US9365502, MQ-31)
Affinity DataIC50: 61nMAssay Description:The IC50 values for non-competitive displacers of [35S]-TBPS from the picrotoxin binding site on GABAA receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM235897(US9365502, MQ-33)
Affinity DataIC50: 62nMAssay Description:The IC50 values for non-competitive displacers of [35S]-TBPS from the picrotoxin binding site on GABAA receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-4(Rat)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM235907(US9365502, MQ-39)
Affinity DataIC50: 65nMAssay Description:The IC50 values for non-competitive displacers of [35S]-TBPS from the picrotoxin binding site on GABAA receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2017
Entry Details
Go to US Patent

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