Compile Data Set for Download or QSAR
Report error Found 693 Enz. Inhib. hit(s) with Target = 'GTPase KRas [Q61H]'
TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785348BDBM785348(US12466840, Example Ex-5)
Affinity DataIC50: 0.970nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785347BDBM785347(US12466840, Example Ex-4)
Affinity DataIC50: 1nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785345BDBM785345(US12466840, Example Ex-2)
Affinity DataIC50: 1.20nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785344BDBM785344(US12466840, Example Ex-1)
Affinity DataIC50: 1.40nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785349BDBM785349(US12466840, Example Ex-6)
Affinity DataIC50: 1.80nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 785350BDBM785350(US12466840, Example Ex-7)
Affinity DataIC50: 2.80nMAssay Description:To assemble the preformed TR-FRET complexes, each biotinylated RAS protein is diluted to 2 μM in an EDTA Buffer (20 mM HEPES pH 7.5, 50 mM sodium chl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/2/2026
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591941BDBM591941(US11566007, Example A621)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750953BDBM750953(US20250195521, Example A415)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591621BDBM591621(US11566007, Example A299)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591619BDBM591619(US11566007, Example A297)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591918BDBM591918(US11566007, Example A598)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591709BDBM591709(US11566007, Example A388)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 751049BDBM751049(US20250195521, Example A501)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 751151BDBM751151(US20250195521, Example A594)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 751164BDBM751164(US20250195521, Example A605)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750672BDBM750672(US20250195521, Example A159)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750799BDBM750799(US20250195521, Example A275)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 751098BDBM751098(US20250195521, Example A546)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 751132BDBM751132(US20250195521, Example A577)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591942BDBM591942(US11566007, Example A622)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591940BDBM591940(US11566007, Example A620)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750724BDBM750724(US20250195521, Example A205)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750723BDBM750723(US20250195521, Example A204)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591951BDBM591951(US11566007, Example A631)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750774BDBM750774(US20250195521, Example A250)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750773BDBM750773(US20250195521, Example A25)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591949BDBM591949(US11566007, Example A629)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750762BDBM750762(US20250195521, Example A24)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750758BDBM750758(US20250195521, Example A236)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591953BDBM591953(US11566007, Example A633)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750752BDBM750752(US20250195521, Example A230)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750747BDBM750747(US20250195521, Example A226)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750689BDBM750689(US20250195521, Example A174)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591926BDBM591926(US11566007, Example A606)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591925BDBM591925(US11566007, Example A605)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591931BDBM591931(US11566007, Example A611)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591929BDBM591929(US11566007, Example A609)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591928BDBM591928(US11566007, Example A608)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591932BDBM591932(US11566007, Example A612)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591975BDBM591975(US11566007, Example A655)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750812BDBM750812(US20250195521, Example A287)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591974BDBM591974(US11566007, Example A654)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591973BDBM591973(US11566007, Example A653)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750810BDBM750810(US20250195521, Example A285)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591976BDBM591976(US11566007, Example A656)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750805BDBM750805(US20250195521, Example A280)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750830BDBM750830(US20250195521, Example A302)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591982BDBM591982(US11566007, Example A662)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 750826BDBM750826(US20250195521, Example A3)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [Q61H](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 591981BDBM591981(US11566007, Example A661)
Affinity DataIC50: 55nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

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