Compile Data Set for Download or QSAR
Report error Found 598 Enz. Inhib. hit(s) with Target = 'G protein-coupled receptor'
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  12nMAssay Description:Binding affinity to GRK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  110nMAssay Description:Binding affinity to GRK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataKd:  17nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  110nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  12nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  37nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor 119(Dog)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106206(CHEMBL3598099)
Affinity DataEC50:  6.10nMAssay Description:Agonist activity at canine GPR119 by HTRF cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2016
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to GRK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  140nMAssay Description:Binding affinity to GRK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13535(N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidin...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to GRK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to GRK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to GRK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM27817(2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50332294(N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)...)
Affinity DataKd:  170nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  140nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM17055((9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydr...)
Affinity DataKd:  590nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKd:  4.20E+3nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM15244(cid_3038525 | 5-(2,6-dichlorophenyl)-2-[(2,4-diflu...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM26300(cid_16007391 | 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)a...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM24654(pyrazole diamide, 33 | 4-N-(2,6-dichlorobenzene)-3...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31088(1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50309910(N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  97nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25084(JMC504279 Compound 6 | 3-[2,4-diamino-6-(3-hydroxy...)
Affinity DataKd:  6.20E+3nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355500(CHEMBL1908394 | US9695172, GSK461364)
Affinity DataKd:  2.80E+3nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataKd:  2.30E+3nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM31095(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Affinity DataKd:  370nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM60589(6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50128285(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmet...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM32362(cid_11617559 | GW-2580 | 5-[[3-methoxy-4-[(4-metho...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataKd:  3.50E+3nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM26474(GW-786034 | JMC514632 Compound 13 | 5-({4-[(2,3-di...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetG protein-coupled receptor kinase 4(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50355501(RUXOLITINIB PHOSPHATE | INCB-018424 | RUXOLITINIB ...)
Affinity DataKd:  6.10E+3nMAssay Description:Binding constant for GRK4 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
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