Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with Target = 'Eukaryotic peptide chain release factor GTP-binding subunit'
LigandPNGBDBM526281(5-(((1S,2S)-2- (dimethylamino)cyclohexyl) (methyl)...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM50631119(CHEMBL4170596)
Affinity DataEC50:  0.300nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631150(CHEMBL5408444)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631149(CHEMBL5419778)
Affinity DataEC50:  70nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631148(CHEMBL5410293)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631147(CHEMBL5427589)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631146(CHEMBL5427975)
Affinity DataEC50:  100nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631145(CHEMBL5407904)
Affinity DataEC50:  21nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631144(CHEMBL5428693)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631143(CHEMBL5430384)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631142(CHEMBL5394519)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631141(CHEMBL5398719)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631140(CHEMBL5403728)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50631139(CHEMBL5437182)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM65497(CC-220 (Compound 6) | US9694015, 6.4S)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged GSPT1 degradation in human DF15 cells incubated for 20 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM526282(5-(((1S,2S)-2- (dimethylamino)cyclohexyl)amino)-2-...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526280(3-(5-(((1S,2S)-2- (methylamino)cyclohexyl)amino)-1...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526270(US11185537, Compound Mix)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526274(2-(2,6-dioxopiperidin-3- yl)-5-(methyl((1S,2S)-2- ...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526273(2-(2,6-dioxopiperidin-3-yl)-5-(((1S,2S)-2- (ethyla...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526272(5-(((1S,2S)-2-aminocyclohexyl) (methyl)amino)- 2-(...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526271(2-(2,6-dioxopiperidin-3- yl)-5-(methyl((1S,2S)-2- ...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526270(US11185537, Compound Mix)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526265(3-(5-(((1S,2S)-2- (isopropylamino)cyclohexyl)amino...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526078(US11185537, Compound I-9 | US11185537, Compound I-...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526078(US11185537, Compound I-9 | US11185537, Compound I-...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526020(3-(5-(((1S,2S)-2-(benzyloxy) cyclohexyl)amino)- 1-...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM526006(3-(5-(((1S,2S)-2- (benzylamino)cyclohexyl)amino)-1...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM525983(3-(5-(methyl((1R,2R)-2- (methylamino)cyclohexyl)am...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM525977(3-(5-(((1S,2S)-2- hydroxycyclohexyl)amino)-1- oxoi...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
Go to US Patent

TargetEukaryotic peptide chain release factor GTP-binding subunit(Baker's yeast)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50482421(TERAIODOPHENOLPHATHALIN)
Affinity DataEC50:  1.00E+5nMAssay Description:Inhibition of yeast prion protein Sup35 infection of PSI yeast spheroplast cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetEukaryotic peptide chain release factor GTP-binding subunit(Baker's yeast)
University of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50482421(TERAIODOPHENOLPHATHALIN)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of polyhistidine tagged yeast prion protein Sup35 expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid polymerizatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed