Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor/Interleukin-3'
TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547888(WO2022090481, Example I-107)
Affinity DataIC50: 633nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547983(WO2022090481, Example I-204)
Affinity DataIC50: 816nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 950nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 978nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 1.06E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547941(WO2022090481, Example I-162)
Affinity DataIC50: 1.37E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547965(WO2022090481, Example I-186)
Affinity DataIC50: 1.63E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547807(WO2022090481, Example I-064 | WO2022090481, Exampl...)
Affinity DataIC50: 2.94E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM547940(WO2022090481, Example I-161)
Affinity DataIC50: 3.80E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481

TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 5.00E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 5.00E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor/Interleukin-3(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib |...)
Affinity DataIC50: 5.00E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
WIPO WO2022090481