Compile Data Set for Download or QSAR
Report error Found 5703 Enz. Inhib. hit(s) with Target = 'Autotaxin'
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50439704(CHEMBL2418934)
Affinity DataEC50:  4.44E+3nMAssay Description:Activation of C-terminal FLAG-tagged human recombinant autotaxin using paranitrophenyl thymidine monophosphate as substrate measured every 2 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50439706(CHEMBL2418933)
Affinity DataEC50:  4.31E+3nMAssay Description:Activation of C-terminal FLAG-tagged human recombinant autotaxin using paranitrophenyl thymidine monophosphate as substrate measured every 2 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50439703(CHEMBL2418930)
Affinity DataEC50:  2.79E+3nMAssay Description:Activation of C-terminal FLAG-tagged human recombinant autotaxin using paranitrophenyl thymidine monophosphate as substrate measured every 2 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50200622(CHEMBL3917975)
Affinity DataEC50:  25nMAssay Description:Inhibition of human recombinant ATX/LPC 18:1-mediated mouse 4T1 cell migration after overnight incubation by Transwell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataEC50:  100nMAssay Description:Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as AKT phosphorylation level incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataEC50:  60nMAssay Description:Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as AKT phosphorylation level incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50605405(CHEMBL5196449)
Affinity DataEC50:  100nMAssay Description:Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as ERK phosphorylation level incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataEC50:  60nMAssay Description:Inhibition of LPA-mediated ATX activation in human BJeH cells assessed as ERK phosphorylation level incubated for 30 mins by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50605406(CHEMBL5190935)
Affinity DataEC50:  186nMAssay Description:Inhibition of LPA-mediated ATX activation in human MDA-MB-231 cells assessed as reduction in cell migration incubated for 4 hrs in using18:1 LPC as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM620080(2-((2-ethyl-6-(5-fluoro-6-(3-hydroxyazetidin-1-car...)
Affinity DataIC50: 0nMAssay Description:The tested compounds were dissolved with dimethyl sulfoxide (DMSO) to prepare 20 mM of stock solutions, the stock solutions were subjected to 4-fold ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50187686(CHEMBL3828074 | US9670204, 2 2-((2-ethyl-6-(4-(2-(...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human ATX using FS3 as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50596095(CHEMBL5183599)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of human ATX using FS-3 as substrate preincubated for 45 mins followed by substrate addition measured every 1 min for 30 mins by fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50540865(CHEMBL4640012)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of human ATX pre-incubated for 45 mins before fluorogenic substrate-3 addition and measured every minute for 30 mins by fluorescence based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258501(US9493486, 1.23 | US10633384, Example 1.23)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258574(US9493486, 12.36 | US10633384, Example 12.36)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258575(US9493486, 12.37 | US10633384, Example 12.37)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258580(US9493486, 12.42 | US10633384, Example 12.42)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258581(US9493486, 12.43 | US10633384, Example 12.43)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258585(US9493486, 13.01 | US10633384, 13.01)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258590(US9493486, 15B)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50187688(CHEMBL3828650 | US10913745, Example 1.11)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human C-terminal His-tagged ATX expressed in HEK293E cells using lysophosphatidylcholine as substrate preincubated with enz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2017
Entry Details Article
PubMed
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM50200622(CHEMBL3917975)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303657((3S)-N-[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadi...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303658((3S)-N-[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadi...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303659((3S)-N-[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadi...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303660((3S)-N-[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadi...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303661((3S)-1-[4-(azepan-1- ylmethyl)phenyl]- N-[5-[2- (4...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303662((3S)-N-[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadi...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303663((3S)-N-[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadi...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303664((3S)-N-[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadi...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303698(5-[2-(4- chlorophenyl)ethyl]-N-[1- [4-(morpholino-...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303716((3S)-N-[5-[2-(4- chlorophenyyl) ethyl]isoxazol- 3-...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303779((3S)-N-[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadi...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM303780((3S)-N-[5-[2-(4- chlorophenyl)ethyl]- 1,3,4-thiadi...)
Affinity DataIC50: 1nMAssay Description:Measuring ATX activity using an enzyme coupled Quanta Red assay (Thermo Scientific Pierce Protein Research Products, Product #15159) was determined a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258501(US9493486, 1.23 | US10633384, Example 1.23)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258574(US9493486, 12.36 | US10633384, Example 12.36)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258575(US9493486, 12.37 | US10633384, Example 12.37)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258580(US9493486, 12.42 | US10633384, Example 12.42)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258581(US9493486, 12.43 | US10633384, Example 12.43)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM258585(US9493486, 13.01 | US10633384, 13.01)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM440743((-)-2-Fluoro-4-(trifluoromethoxy)benzyl 2-(4,5,6,7...)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM442707(US10647719, Example 1.18 | [6-chloro-3-(2,2-)
Affinity DataIC50: 1nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM442712(US10647719, Example 1.23 | [6-chloro-3-(2,2-)
Affinity DataIC50: 1nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM442737(US10647719, Example 1.34 | 4-[5-[2-cyclopyropyl-6-...)
Affinity DataIC50: 1nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM450546(US10676446, Example 131 | N-[(3-Chloro-4-cyanophen...)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM450548(US10676446, Example 133 | N-[(3-Chloro-4- cyanophe...)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM450549(US10676446, Example 134 | N-[(3-Chloro-4- cyanophe...)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM450551(US10676446, Example 135 | N-[(3-Chloro-4- cyanophe...)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM450552(US10676446, Example 136 | N-[(3-Chloro-4- cyanophe...)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
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TargetAutotaxin(Human)
The University of Memphis

Curated by ChEMBL
LigandPNGBDBM450562(US10676446, Example 146 | N-Cyclopropyl-N-[(3,4-di...)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
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