Compile Data Set for Download or QSAR
Report error Found 420 Enz. Inhib. hit(s) with Target = 'Diacylglycerol lipase-alpha'
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 0.251nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 0.251nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using PNP butyrate as substrate by colorimetric surro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic sur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 0.398nMAssay Description:Inhibition of human C-terminal HA-tagged DAGLalpha expressed in HEK293F cell membrane fractions using DiFMU-octanoate as substrate by fluorogenic sur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: 0.501nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM434879(US10583137, Compound 17 | tert-Butyl 3-benzyl-4-(4...)
Affinity DataIC50: 0.501nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50148158(CHEMBL3764017)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211240(CHEMBL3897587)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50: 0.631nMAssay Description:Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211265(CHEMBL3954476)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211271(CHEMBL3913807)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211266(CHEMBL3906477)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50148192(CHEMBL3765578)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM24567(Tetrahydrolipstatin | CHEMBL175247 | Xenical | (2S...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant DAGLalpha expressed in African green monkey COS cells using sn-1-stearoyl-2-[14C]-arachidonoyl-glycerol as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211269(CHEMBL3970032)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211236(CHEMBL2144065)
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50: 1.30nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211257(CHEMBL3895863 | US10583137, Compound 14)
Affinity DataIC50: 1.30nMAssay Description:Inhibition human DAGLalpha expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211240(CHEMBL3897587)
Affinity DataIC50: 2nMAssay Description:Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211271(CHEMBL3913807)
Affinity DataIC50: 2nMAssay Description:Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211260(CHEMBL3964338)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519345(CHEMBL4447844)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50148184(CHEMBL3763853)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50148188(CHEMBL3763826)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50148193(CHEMBL3765716)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211265(CHEMBL3954476)
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211233(CHEMBL3941507)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519345(CHEMBL4447844)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human DAGLalpha expressed in HEK293T cell membrane fractions using PNP butyrate as substrate preincubated for 20 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519345(CHEMBL4447844)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human DAGLalpha expressed in HEK293T cell membrane fractions using PNP butyrate as substrate preincubated for 20 mins followed by subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50161525(1-(oxazolo[4,5-b]pyridin-2-yl)-9-phenylnonan-1-one...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50519341(CHEMBL4437021)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of mouse DAGL-alpha expressed in HEK293T cell membranes pre-incubated for 20 mins before PNP-butyrate substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50148154(CHEMBL3763831)
Affinity DataIC50: 4nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 4nMAssay Description:Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50532882(CHEMBL4476210)
Affinity DataIC50: 4nMAssay Description:Inhibition of human GST-tagged DAGLalpha expressed in HEK293F cell membranes using 1-stearoyl-2-arachidonoyl-sn-glycerol as substrate preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211256(CHEMBL3921538)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211277(CHEMBL3903742)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211274(CHEMBL3916842)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50148187(CHEMBL3764093)
Affinity DataIC50: 6nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211273(CHEMBL3986579)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211236(CHEMBL2144065)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of full length recombinant human DAGLalpha expressed in HEK293T cell membranes using PNP butyrate as substrate by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211261(CHEMBL3897762)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211262(CHEMBL3922787)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Mouse)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211266(CHEMBL3906477)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of MB064 probe binding to DAGLalpha in mouse brain membrane proteome preincubated for 30 mins followed by MB064 probe addition measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50147618(CHEMBL3765022)
Affinity DataIC50: 8nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50148191(CHEMBL3763430)
Affinity DataIC50: 8nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM24567(Tetrahydrolipstatin | CHEMBL175247 | Xenical | (2S...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DAGLalpha expressed in HEK293T cell membrane using [14C]SAG substrate in detergent free solution by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50147612(CHEMBL3765158)
Affinity DataIC50: 11nMAssay Description:Inhibition of full length human C-terminal HA-tagged DAGLalpha expressed in HEK293 cell membrane using DAG as substrate incubated for 20 mins by LC-M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2017
Entry Details Article
PubMed
TargetDiacylglycerol lipase-alpha(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50211255(CHEMBL3925845)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human DAGLalpha expressed in HEK293T cell membranes overexpressing MAGL using natural substrate 1-stearoyl-2-arachidonoly-s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2018
Entry Details Article
PubMed
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