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Report error Found 33 Enz. Inhib. hit(s) with Target = 'DNA polymerase subunit gamma-1'
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM21687(deoxyguanosine triphosphate | ({[({[(2R,3S,5R)-5-(...)
Affinity DataKd:  800nMAssay Description:Binding affinity to exonuclase deficient human recombinant DNA polymerase gamma E200A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50478747(Acyclovir triphosphate)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to exonuclase deficient human recombinant DNA polymerase gamma E200A mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50408427(CHEMBL483492)
Affinity DataIC50: 500nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50408426(CHEMBL2092833)
Affinity DataIC50: 1.50E+3nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50408426(CHEMBL2092833)
Affinity DataIC50: 1.50E+3nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50408425(CHEMBL2092835)
Affinity DataIC50: 2.00E+3nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50448482(CHEMBL3126408)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of DNA polymerase-gamma (unknown origin) assessed as incorporation of Br(d)UTP by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50191511(2-{4-[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DNA polymerase gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50428818(CHEMBL3142662)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of rat DNA polymerase beta using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50251277(Kasanosin A | CHEMBL458178)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human DNA polymerase gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50408427(CHEMBL483492)
Affinity DataIC50: 5.00E+4nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50408425(CHEMBL2092835)
Affinity DataIC50: 5.00E+4nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50335554(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)
Affinity DataIC50: 5.94E+4nMAssay Description:Inhibition of human DNA polymerase gamma by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50251278(Kasanosin B | CHEMBL457091)
Affinity DataIC50: 7.29E+4nMAssay Description:Inhibition of human DNA polymerase gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50205415(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Affinity DataIC50: 8.00E+4nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50333127((beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphat...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50408428(CHEMBL2092834)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50336502(10-acetyl-11-(2,4-dichlorophenyl)-3,3-dimethyl-2,3...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50336503(10-acetyl-11-(3-(benzyloxy)-4-methoxyphenyl)-3,3-d...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50090910(6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50021053(CHEMBL3287609)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50408428(CHEMBL2092834)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50335556([({[({2-[2-amino-6-(cyclopropylamino)-9H-purin-9-y...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of human DNA polymerase gamma by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50428818(CHEMBL3142662)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human DNA polymerase kappa using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50428818(CHEMBL3142662)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human DNA polymerase eta using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50428818(CHEMBL3142662)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of calf TdT polymerase measured at 37 degC for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50428818(CHEMBL3142662)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human DNA polymerase mu using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50428818(CHEMBL3142662)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human DNA polymerase gamma using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50428818(CHEMBL3142662)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human DNA polymerase gamma using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM21688(CHEMBL201900 | 1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-...)
Affinity DataKi:  6.84E+5nM ΔG°:  -18.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed
TargetDNA polymerase subunit gamma-1(Human)
The University of Texas

Curated by ChEMBL
LigandPNGBDBM21686(HBEMAU | CHEMBL327687 | 3-(4-hydroxybutyl)-6-(3-et...)
Affinity DataKi: >1.01E+6nM ΔG°: >-17.8kJ/molepH: 7.5 T: 2°CAssay Description:Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2008
Entry Details Article
PubMed