Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with Target = 'DNA polymerase kappa'
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50191327(CHEMBL3960997)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50318907(CHEMBL1014 | TCV-116 | candesartancilexetil | Atac...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50250399(5-Hydroxy-4-{(R)-6-hydroxy-5-[(E)-4-methyl-6-(2,6,...)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues)-mediated TLS past acrolein derived ring-opened reduced form of gamma-HOPdG lesions prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50356642(CHEMBL1917196)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA tem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2013
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50356643(CHEMBL1917198)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA tem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2013
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50318907(CHEMBL1014 | TCV-116 | candesartancilexetil | Atac...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50104668(CHEMBL3593571)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of C-terminal His6-tagged human DNA polymerase kappa (1 to 560 residues) expressed in Escherichia coli using poly(dA)/oligo(dT)18 and [3H]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50191327(CHEMBL3960997)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human DNA polymerase kappa (19 to 526 residues) preincubated for 15 mins followed by replicating non-damaged DNA substrate addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataIC50: 4.86E+4nMAssay Description:Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50379293(CHEMBL2011648)
Affinity DataIC50: 5.98E+4nMAssay Description:Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50375301(CHEMBL260980)
Affinity DataIC50: 5.98E+4nMAssay Description:Inhibition of human DNA polymerase kappaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50375300(TALAROFLAVONE)
Affinity DataIC50: 8.65E+4nMAssay Description:Inhibition of human DNA polymerase kappaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50379294(CHEMBL2011647)
Affinity DataIC50: 8.89E+4nMAssay Description:Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50448690(CHEMBL3127728)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of C-terminal His-6-tagged human DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50448688(Pecilocin | Variotin)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of C-terminal His-6-tagged human DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50448689(CHEMBL3127730)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of C-terminal His-6-tagged human DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50448691(CHEMBL3127729)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of C-terminal His-6-tagged human DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataKi:  9.85E+3nMAssay Description:Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDNA polymerase kappa(Human)
University of Connecticut Health Center

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataKi:  1.81E+4nMAssay Description:Non-competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using ploy(dA)/oligo(dT)18 as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed