Compile Data Set for Download or QSAR
Report error Found 1258 Enz. Inhib. hit(s) with Target = 'DNA (cytosine-5)-methyltransferase 1'
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031315(CHEMBL3358028)
Affinity DataKd:  910nMAssay Description:Binding affinity to N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031317(CHEMBL3358015)
Affinity DataKd:  1.09E+3nMAssay Description:Binding affinity to N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataEC50:  1.02E+4nMAssay Description:Inhibition of human His-DNMT1 using [methyl-3H]SAM as substrate after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239284(CHEMBL4096360)
Affinity DataEC50:  4.60E+4nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239285(CHEMBL4096869)
Affinity DataEC50:  2.40E+4nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239286(CHEMBL4084601)
Affinity DataEC50:  3.20E+4nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239287(CHEMBL4100095)
Affinity DataEC50:  7.30E+4nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239288(CHEMBL4097685)
Affinity DataEC50:  2.60E+4nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239290(CHEMBL4099197)
Affinity DataEC50:  1.00E+5nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239292(CHEMBL4070549)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239291(CHEMBL4091463)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239293(CHEMBL4076088)
Affinity DataEC50:  3.00E+4nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50239289(CHEMBL4096752)
Affinity DataEC50:  2.70E+4nMAssay Description:Inhibition of full length His-tagged human DNMT1 using SAM/[methyl-3H]SAM assessed as reduction of methylation in biotinylated hemimethylated DNA dup...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2019
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506776(CHEMBL4442279)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506774(CHEMBL4470149)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506782(CHEMBL4461581)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506783(CHEMBL4582042)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506784(CHEMBL4527662)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506785(CHEMBL4537137)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506786(CHEMBL4469152)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506787(CHEMBL4558658)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506789(CHEMBL4470318)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506788(CHEMBL4526979)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50506790(CHEMBL4574840)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646361(CHEMBL5591922)
Affinity DataKd:  40nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646362(CHEMBL5584171)
Affinity DataKd:  35nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646363(CHEMBL5592699)
Affinity DataKd:  55nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646364(CHEMBL5593675)
Affinity DataKd:  56nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646365(CHEMBL5594440)
Affinity DataKd:  49nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646366(CHEMBL5592841)
Affinity DataKd:  37nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646367(CHEMBL5595428)
Affinity DataKd:  36nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646368(CHEMBL5591775)
Affinity DataKd:  28nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646361(CHEMBL5591922)
Affinity DataKd:  1.16E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646362(CHEMBL5584171)
Affinity DataKd:  145nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646363(CHEMBL5592699)
Affinity DataKd:  841nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646364(CHEMBL5593675)
Affinity DataKd:  679nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646365(CHEMBL5594440)
Affinity DataKd:  666nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646366(CHEMBL5592841)
Affinity DataKd:  160nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646367(CHEMBL5595428)
Affinity DataKd:  183nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646368(CHEMBL5591775)
Affinity DataKd:  127nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50389497(CHEMBL1564869)
Affinity DataKd:  9.46E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50646361(CHEMBL5591922)
Affinity DataKd:  4.09E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50389497(CHEMBL1564869)
Affinity DataKd:  9.46E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50648795(CHEMBL5613455)
Affinity DataEC50:  1.09E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataEC50:  750nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50648799(CHEMBL5613728)
Affinity DataEC50:  1.18E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM491199(US10975056, Example 143)
Affinity DataEC50:  40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50443016(CHEMBL3087498)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM50590375(CHEMBL5187396)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Unit£

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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