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Report error Found 149 Enz. Inhib. hit(s) with Target = 'Cytochrome c oxidase subunit 2'
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  153nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  449nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50587908(CHEMBL5193790)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of ovine COX-2 colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50587909(CHEMBL5174073)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of ovine COX-2 colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM22369(CHEMBL122 | MK 0966 | 4-(4-methanesulfonylphenyl)-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50029600(CHEMBL42485 | 5-bromo-2-(4-fluorophenyl)-3-(4-(met...)
Affinity DataIC50: 21nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant COX-2 using [1-14C] arachidonic acid as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50229774(N-hydroxy-4-(5-methyl-3-phenylisoxazol-4-yl)benzen...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant cyclooxygenase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 43nMAssay Description:Inhibition of ovine COX-2 colorimetric enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326830(2-(4-azido)phenyl)-8-benzoyl-quinoline-4-carboxyli...)
Affinity DataIC50: 57nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50635952(CHEMBL5568253)
Affinity DataIC50: 58nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 60nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326828(8-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-...)
Affinity DataIC50: 69nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50635949(CHEMBL5565096)
Affinity DataIC50: 75nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326829(6-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-...)
Affinity DataIC50: 77nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326831(2-(4-azido)phenyl)-6-benzoyl-quinoline-4-carboxyli...)
Affinity DataIC50: 77nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326826(2-(4-acetamido)phenyl)-8-benzoyl-quinoline-4-carbo...)
Affinity DataIC50: 80nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50326827(2-(4-acetamido)phenyl)-6-benzoyl-quinoline-4-carbo...)
Affinity DataIC50: 85nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 90nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid as substrate measured after 2 mins by colorimetric enzyme immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM679785(US12011433, Compound MPA450)
Affinity DataIC50: 90nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50300870(2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxyli...)
Affinity DataIC50: 91nMAssay Description:Inhibition of sheep COX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM679775(US12011433, Compound MPA236)
Affinity DataIC50: 100nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50587914(CHEMBL5200917)
Affinity DataIC50: 110nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid as substrate measured after 2 mins by colorimetric enzyme immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM679777(US12011433, Compound MPA361)
Affinity DataIC50: 120nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50635950(CHEMBL5568511)
Affinity DataIC50: 134nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50635951(CHEMBL5568474)
Affinity DataIC50: 144nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 160nMAssay Description:Inhibition of ovine COX-2 by colorimetric inhibitor screening assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50587915(CHEMBL5196989)
Affinity DataIC50: 170nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid as substrate measured after 2 mins by colorimetric enzyme immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50598758(CHEMBL5199117)
Affinity DataIC50: 190nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50598765(CHEMBL5207189)
Affinity DataIC50: 240nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM679767(US12011433, Compound GAMOF11)
Affinity DataIC50: 270nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 293nMAssay Description:Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 300nMAssay Description:Inhibition of COX-2 in LPS-stimulated human whole blood assessed as reduction in PGE2 production by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50515743(CHEMBL4448990)
Affinity DataIC50: 367nMAssay Description:Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50598750(CHEMBL5193981)
Affinity DataIC50: 490nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50515744(CHEMBL4441570)
Affinity DataIC50: 513nMAssay Description:Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 540nMAssay Description:Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2020
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50598754(CHEMBL5173923)
Affinity DataIC50: 550nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50598757(CHEMBL5191029)
Affinity DataIC50: 560nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM50646205(CHEMBL5591030)
Affinity DataIC50: 560nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM17638(indometacin | Indocin | 2-{1-[(4-chlorophenyl)carb...)
Affinity DataIC50: 610nMAssay Description:Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2020
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM679765(US12011433, Compound GlaMOF0)
Affinity DataIC50: 700nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetCytochrome c oxidase subunit 2(Sheep)
Dpsr University

Curated by ChEMBL
LigandPNGBDBM679786(US12011433, Compound MPA362)
Affinity DataIC50: 800nMAssay Description:The target compounds were evaluated for their ability to inhibit ovine COX-1 and COX-2 enzyme catalytic activity (percent inhibition at 50 mm, unless...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2024
Entry Details
Go to US Patent

TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50515745(CHEMBL4474644)
Affinity DataIC50: 915nMAssay Description:Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50598766(CHEMBL5170447)
Affinity DataIC50: 930nMAssay Description:Inhibition of human COX-2 assessed as by fluorescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50558934(CHEMBL4754218)
Affinity DataIC50: 980nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM13063(CHEMBL865 | cid_119607 | Bextra | VLX | 4-(5-methy...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant cyclooxygenase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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