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Report error Found 180 Enz. Inhib. hit(s) with Target = 'Cytochrome b-245 heavy chain'
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataEC50:  500nMAssay Description:Inhibition of NOX2 (unknown origin) transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50497270(CHEMBL3347551)
Affinity DataIC50: 30nMAssay Description:Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of lithium dodecyl sulphate-stimulated ROS generation preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50497271(CHEMBL3347550)
Affinity DataIC50: 30nMAssay Description:Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of lithium dodecyl sulphate-stimulated ROS generation preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50206334(Diphenylene iodonium chloride | dibenziodolium chl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of NOX2 in human PLB-985 cells assessed as inhibition of PMA-induced hydrogen peroxide production pretreated for 15 mins followed by PMA s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628589(CHEMBL4210329)
Affinity DataIC50: 100nMAssay Description:Inhibition of human NOX2 transfected in PLB-985 cells assessed as PMA-induced hydrogen peroxide pre-incubated for 10 and measured after 15 mins by Am...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628597(CHEMBL5413611)
Affinity DataIC50: 149nMAssay Description:Inhibition of NOX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human NOX2 expressed in HEK cells assessed as inhibition of ionomycin-induced hydrogen peroxide production pre-incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50630401(CHEMBL5426199)
Affinity DataIC50: 490nMAssay Description:Inhibition of NOX-2 dependent superoxide generation in PMA-differentiated human PLB-985 cells incubated for 1 hr by WST-1 based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50218664(CHEMBL5275943)
Affinity DataIC50: 500nMAssay Description:Inhibition of NOX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612720(CHEMBL5279528)
Affinity DataIC50: 520nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50071058(CHEMBL301982 | cid_4274774 | (2R,4aS,6aS,12bR,14aS...)
Affinity DataIC50: 590nMAssay Description:Inhibition of NOX2 in human PLB-985 cells assessed as inhibition of PMA-induced hydrogen peroxide production pretreated for 15 mins followed by PMA s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628600(CHEMBL5436229)
Affinity DataIC50: 740nMAssay Description:Inhibition of NOX2 (unknown origin) transfected in HEK293 cells assessed as inhibition of hydrogen peroxide production pe-incubated for 15 mins and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM713698(4-hydroxy-N-[2-(2-hydroxyphenyl)ethyl]- 2,6-dimeth...)
Affinity DataIC50: 870nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM713693(N-[2-(2-hydroxyphenyl)ethyl]-2,4,6- trimethylbenze...)
Affinity DataIC50: 900nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM713695(6-chloro-3-hydroxy-N-[2-(2- hydroxyphenyl)ethyl]-2...)
Affinity DataIC50: 900nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612719(CHEMBL5285816)
Affinity DataIC50: 910nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612714(CHEMBL5279646)
Affinity DataIC50: 990nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628595(CHEMBL5416189)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of NOX2 (unknown origin) expressed in HEK293T cells assessed as inhibition of PMA-induced superoxide production preincubated for 15 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM713697(N-[2-(2-hydroxyphenyl)ethyl]-4-methoxy- 2,6-dimeth...)
Affinity DataIC50: 1.00E+3nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of NOX-2 dependent superoxide generation in PMA-differentiated human PLB-985 cells incubated for 1 hr by WST-1 based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50630362(CHEMBL5427803)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of NOX-2 dependent superoxide generation in PMA-differentiated human PLB-985 cells incubated for 1 hr by WST-1 based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of human NOX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612709(CHEMBL5282245)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612711(CHEMBL5278688)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM713694(4-bromo-2,6-dichloro-N-[2-(2- hydroxyphenyl)ethyl]...)
Affinity DataIC50: 1.50E+3nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/29/2025
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612712(CHEMBL5269753)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50630363(CHEMBL5410678)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of NOX-2 dependent superoxide generation in PMA-differentiated human PLB-985 cells incubated for 1 hr by WST-1 based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM682705(US20240208944, Compound TG15-139)
Affinity DataIC50: 1.65E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612718(CHEMBL5269857)
Affinity DataIC50: 1.66E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM318936(US10173988, Compound A)
Affinity DataIC50: 1.68E+3nMAssay Description:Cells: Human blood was purchased in buffy coat, prepared the same day for isolation of neutrophils, from Labjoy AB, Lund, Sweden. Blood components we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612701(CHEMBL5266372)
Affinity DataIC50: 1.76E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612704(CHEMBL5266063)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612710(CHEMBL5290483)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of human NOX2 expressed in HEK293T cells assessed as inhibition of LPS-induced superoxide production pre-incubated for 45 mins and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612703(CHEMBL5269456)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628598(CHEMBL5424942)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human NOX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM42010(3-[4-[4-(2-hydroxyphenyl)piperazin-1-yl]-4-oxidany...)
Affinity DataIC50: 2.30E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM682710(US20240208944, Compound TG17-57)
Affinity DataIC50: 2.40E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612706(CHEMBL5283659)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50497042(CHEMBL3249799)
Affinity DataIC50: 2.52E+3nMAssay Description:Inhibition of human NOX2 expressed in HEK293T cells assessed as inhibition of LPS-induced superoxide production pre-incubated for 45 mins and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612707(CHEMBL5287636)
Affinity DataIC50: 2.72E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612715(CHEMBL5287582)
Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612705(CHEMBL5291222)
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612713(CHEMBL5271584)
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50612716(CHEMBL5270712)
Affinity DataIC50: 2.96E+3nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50630403(CHEMBL5429601)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of NOX-2 dependent superoxide generation in PMA-differentiated human PLB-985 cells incubated for 1 hr by WST-1 based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM42323(SMR000033635 | MLS000047624 | cid_81131 | 1-(10H-p...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human NOX2 transfected in HEK293T cells incubated for 16 hrs ans measured after 30 mins by luminol-chemiluminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50630348(CHEMBL5419067)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of NOX2 (unknown origin) transfected in COS cells assessed as reduction in PMA-stimulated H2O2 production preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM682703(US20240208944, Compound TG15-132)
Affinity DataIC50: 3.30E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM682708(US20240208944, Compound LY4-123S)
Affinity DataIC50: 3.30E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

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