Compile Data Set for Download or QSAR
Report error Found 57 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 3A4/3A5'
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 13nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using Midazolam as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490735(DNDI1449875 | CHEMBL1863002)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490750(CHEMBL2334336)
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50014757(CHEMBL137192 | (4-Chloro-phenyl)-(2-chloro-phenyl)...)
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490748(DNDI1435775 | CHEMBL1863056)
Affinity DataIC50: 810nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485474(DNDI1322027 | CHEMBL1862838)
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490744(DNDI1467768 | CHEMBL1862905)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490737(DNDI1538112 | CHEMBL1863288)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485473(DNDI1336037 | CHEMBL1863499)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490736(DNDI1343536 | CHEMBL1863145)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485471(DNDI1335912 | CHEMBL1863383)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485466(DNDI1335913 | CHEMBL1863004)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490742(DNDI1460901 | CHEMBL1863462)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490743(DNDI1434940 | CHEMBL1863046)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485476(DNDI1294211 | CHEMBL1863160)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490749(DNDI1434923 | CHEMBL1862798)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490753(DNDI1465083 | CHEMBL1863455)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485475(DNDI1336031 | CHEMBL1863146)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490741(CHEMBL2334337)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490751(DNDI1434944 | CHEMBL1863306)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490745(DNDI1338491 | CHEMBL1863273)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490746(DNDI1388149 | CHEMBL1863393)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490752(DNDI1551253 | CHEMBL1862941)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485468(DNDI1467766 | CHEMBL1863039)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485467(DNDI1574842 | CHEMBL1863325)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485470(DNDI1342987 | CHEMBL1863007)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485469(DNDI1268111 | CHEMBL1863183)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490738(DNDI1490391 | CHEMBL1863131)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490747(DNDI1449876 | CHEMBL1863090)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490740(DNDI1467767 | CHEMBL1862938)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490739(DNDI1335908 | CHEMBL1862975)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485472(DNDI1330083 | CHEMBL1863379)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate measured for 10 to 30 mins in presence of NADPH regenerating system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate measured for 10 to 30 mins in presence of NADPH regenerating system by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490734(DNDI1402165 | CHEMBL1863136)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: 3.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in pooled human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM106203(US9695174, I-1)
Affinity DataIC50: 3.00E+4nMpH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent

TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50305083(Ko143 | Ko-143 | 3-((3S,6S)-6-Isobutyl-9-methoxy-1...)
Affinity DataIC50: 3.00E+4nMpH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent

TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491626(CHEMBL2386155)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491627(CHEMBL2386145)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491625(CHEMBL2386153)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491624(CHEMBL2386149)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491623(CHEMBL2386150)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491622(CHEMBL2386156)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491621(CHEMBL2386140)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491620(CHEMBL2386141)
Affinity DataIC50: 5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
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