Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 4/G1/S-specific cyclin-E1'
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193087(CHEMBL3897452)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK4/cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458033(CHEMBL4210422)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458026(CHEMBL4207521)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458041(CHEMBL4213744)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458044(CHEMBL4208813)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458049(CHEMBL4214827)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458051(CHEMBL4206061 | US10988476, Compound I-23)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458042(CHEMBL4202644)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458040(CHEMBL4204986)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458047(CHEMBL4212540)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458043(CHEMBL4210299)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458034(CHEMBL4212532 | US10662186, Compound 5 | US1098847...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458032(CHEMBL4205132)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458048(CHEMBL4210944)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50464606(CHEMBL4277900 | US11091476, Example 17)
Affinity DataIC50: 2.62nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458025(CHEMBL4216664)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458027(CHEMBL4213778)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458046(CHEMBL4213756 | US10662186, Compound comparative C...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458035(CHEMBL4213219 | US10662186, Compound comparative B...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458028(CHEMBL4202467)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50464613(CHEMBL4288165 | US11091476, Example 12)
Affinity DataIC50: 4.46nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458030(CHEMBL4218588)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458039(CHEMBL4214156)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458045(CHEMBL4217628)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458038(CHEMBL4205920)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458031(CHEMBL4209352)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458050(CHEMBL4203758)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458029(CHEMBL4204483)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458036(CHEMBL4207796 | US10662186, Compound comparative F...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 14.8nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50458037(CHEMBL4210282)
Affinity DataIC50: 17nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50: 80.9nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/μl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM106950(US8592581, 1)
Affinity DataIC50: 232nMAssay Description:Inhibition of CDK4/cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed