Compile Data Set for Download or QSAR
Report error Found 2516 Enz. Inhib. hit(s) with Target = 'Coagulation factor XII'
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23534(6-methyl-2-oxo-N-(propan-2-yl)-2H-chromene-3-carbo...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23535(N-cyclohexyl-6-methyl-2-oxo-2H-chromene-3-carboxam...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23550(8-methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23551(5-oxo-N-phenyl-6-oxatricyclo[8.4.0.0^{2,7}]tetrade...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23552(7-hydroxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23553(7-methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23554(7-(diethylamino)-2-oxo-N-phenyl-2H-chromene-3-carb...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23561(phenyl 2-oxo-2H-chromene-3-carboxylate | 3-Carboxy...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM23562(phenyl 6-methyl-2-oxo-2H-chromene-3-carboxylate | ...)
Affinity DatapH: 7.9 T: 2°CAssay Description:After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2008
Entry Details Article
PubMed
TargetCoagulation factor XIII A chain(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50033766(CHEMBL3358149)
Affinity DataKd: <100nMAssay Description:Binding affinity to recombinant F13A (unknown origin) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCoagulation factor XIII A chain(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50033803(CHEMBL3358150)
Affinity DataKd:  800nMAssay Description:Binding affinity to recombinant F13A (unknown origin) by microscale thermophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetCoagulation factor XIII A chain [Q652E](Human)
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50608716(CHEMBL5269322)
Affinity DataKd:  2.53E+4nMAssay Description:Binding affinity to human coagulation factor XIIIa by Spectrofluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476445(2-chloro-3,4-dimethylphenyl (3S)-4- (N2-cyclohexyl...)
Affinity DataIC50: 0.100nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476448(2-chloro-3,4-dimethylphenyl (3S)-4- [N-(2-benzyl-2...)
Affinity DataIC50: 0.200nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476452(2-chloro-3,4-dimethylphenyl (3S)-4- [N2-(2-benzyl-...)
Affinity DataIC50: 0.300nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476454(2-chloro-3,4-dimethylphenyl (3S)-4- [N-(2-benzyl-2...)
Affinity DataIC50: 0.300nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476486((2S)-1-[N2-(2-benzyl-2- azaspiro[4.5]dec-8-yl)-N6,...)
Affinity DataIC50: 0.400nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476444(2-chloro-3,4-dimethylphenyl (3S)-4- [N2-(2-benzyl-...)
Affinity DataIC50: 0.5nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476449(2-chloro-3,4-dimethylphenyl (3S)-4- [N2-(2-benzyl-...)
Affinity DataIC50: 0.5nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476515((2S)-N-[(3-chloro-1H-indol-5- yl)methyl]-1-[N-(1-m...)
Affinity DataIC50: 0.5nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476516((2S)-1-{N-[4- (aminomethyl)cyclohexyl]-6- piperidi...)
Affinity DataIC50: 0.600nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476434(2-chlorophenyl (3S)-4-[N2-(2-benzyl- 2-azaspiro[4....)
Affinity DataIC50: 0.700nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476441(2-chlorophenyl (3S)-4-(N-cyclohexyl- 6-piperidin-1...)
Affinity DataIC50: 0.700nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476446(2-chloro-3,4-dimethylphenyl (3S)-4- [N2-cyclohexyl...)
Affinity DataIC50: 0.700nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476479((2S)-1-[N2-(2-benzyl-2- azaspiro[4.5]dec-8-yl)-N6,...)
Affinity DataIC50: 0.800nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476422(2-chlorophenyl (3S)-4-[N2-(2-benzyl- 2-azaspiro[4....)
Affinity DataIC50: 0.900nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476432(2-chlorophenyl (3S)-4-[N-(2-benzyl- 2-azaspiro[4.5...)
Affinity DataIC50: 0.900nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476431(1-chloronaphthalen-2-yl (3S)-3-{[4- (aminomethyl)-...)
Affinity DataIC50: 1nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476453(2-chloro-3,4-dimethylphenyl (3S)-4- [N-(2-benzyl-2...)
Affinity DataIC50: 1nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476399(3-(aminomethyl)-2-chlorophenyl (3S)- 4-(N,3-dicycl...)
Affinity DataIC50: 1.10nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476417(2-chlorophenyl (3S)-4-(N2- cyclohexyl-N6,N6-dimeth...)
Affinity DataIC50: 1.10nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476423(2-chlorophenyl (3S)-4-[N2-(2-benzyl- 2-azaspiro[4....)
Affinity DataIC50: 1.10nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476474((2S)-1-[N2-(2-benzyl-2- azaspiro[4.5]dec-8-yl)-N6,...)
Affinity DataIC50: 1.20nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476447(2-chloro-3,4-dimethylphenyl (3S)-4- [N2,N6-bis(1-m...)
Affinity DataIC50: 1.40nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476482((2S)-4[(4S,5S)-5-(3-cyanophenyl)-4- methyl-4,5-dih...)
Affinity DataIC50: 1.40nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476463((2S)-1-[(2R)-2-[(4- carbamoylcyclohexyl)amino]-2-(...)
Affinity DataIC50: 1.5nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM498923(N-{(3S,4R)-1-[N~2~- (2-benzyl-2- azaspiro[4.5]dec-...)
Affinity DataIC50: 1.5nMAssay Description:Factor XIIa activity determinations were made in 50 mM HEPES buffer containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476368(naphthalen-1-yl (3S)-3-{[4- (aminomethyl)-3- metho...)
Affinity DataIC50: 1.60nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476406(2-chlorophenyl (3S)-4-{(2R)-2- (cyclohexylamino)-2...)
Affinity DataIC50: 1.70nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476433(1-chloronaphthalen-2-yl (3S)-3-{[4- (aminomethyl)-...)
Affinity DataIC50: 1.70nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476523((2S)-N-[4-(aminomethyl)-3- chlorobenzyl]-1-[N-(1-m...)
Affinity DataIC50: 1.70nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476439(2-chlorophenyl (3S)-4-[N-(2-benzyl- 2-azaspiro[4.5...)
Affinity DataIC50: 1.80nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476474((2S)-1-[N2-(2-benzyl-2- azaspiro[4.5]dec-8-yl)-N6,...)
Affinity DataIC50: 1.80nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476426(3-(aminomethyl)-2-chlorophenyl (3S)- 4-[N2-(2-benz...)
Affinity DataIC50: 2.10nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476527((2S)-[N-cyclohexyl-3-(1- cyclohexylpiperidin-4-yl)...)
Affinity DataIC50: 2.40nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476514((2S)-N-(3-chlorobenzyl)-4-[(4S,5S)-4- methyl-5-phe...)
Affinity DataIC50: 2.5nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476407(2-chlorophenyl (3S)-4-[(2R)-2- (cyclohexylamino)-2...)
Affinity DataIC50: 2.60nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476388(1-chloronaphthalen-2-yl (3S)-3-{[4- (aminomethyl)-...)
Affinity DataIC50: 2.70nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476436(1-chloronaphthalen-2-yl (3S)-4-{N2- [4-(aminomethy...)
Affinity DataIC50: 2.90nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
Entry Details
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TargetCoagulation factor XII(Human)
University of Namur

LigandPNGBDBM476518((2S)-1-{N-[4- (aminomethyl)cyclohexyl]-6- piperidi...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
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