Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with Target = 'Coagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2'
LigandPNGBDBM387049(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
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Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387050(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387054(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387055(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387056(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387057(N′-Cyano-1-(4-methoxyphenyl)-7-oxo-6-(2̸...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387058(1-(4-Methoxyphenyl)-7-oxo-6-(1-(3-oxomorpholino)pi...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM19023(BMS-562247 | CHEMBL231779 | 1-(4-methoxyphenyl)-7-...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387083(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387065(1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387068(1-(4-Methoxyphenyl)-7-oxo-6-(2-oxo-[1,4′-bip...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387082(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387077(4-(4-(1-(4-(Difluoromethoxy)phenyl)-7-oxo-3-(trifl...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
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Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387078(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387080(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Affinity DataKi: <10nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387085(3-(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-3-(...)
Affinity DataKi:  30nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387069(1-(4-Methoxyphenyl)-N5-(1-(3-oxomorpholino)piperid...)
Affinity DataKi:  30nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387059(US9938272, Example 8b | US9938272, Example 8a)
Affinity DataKi:  30nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
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LigandPNGBDBM387064(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-1-(4-(...)
Affinity DataKi:  525nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2020
Entry Details
Go to US Patent