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Report error Found 2935 Enz. Inhib. hit(s) with Target = 'Cathepsin B'
TargetCathepsin B(Bovine)
Osaka University of Pharmaceutical Sciences

LigandPNGBDBM16511((2S)-1-[(2S)-2-{[(2S,3S)-3-{[(1S)-1-({[(2-methoxy-...)
Affinity DatapH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2007
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50391540(CHEMBL2147469)
Affinity DataEC50:  200nMAssay Description:Inhibition of cathepsin B using Z-Phe-Arg-MCA as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by fluorimetric a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50391541(CHEMBL2147467)
Affinity DataEC50:  700nMAssay Description:Inhibition of cathepsin B using Z-Phe-Arg-MCA as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by fluorimetric a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.81E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  6.04E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50602545(CHEMBL4596647)
Affinity DataIC50: 0.149nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM420296(med.21724, Compound 61 | peptidomimetic aldehydes ...)
Affinity DataIC50: 0.210nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50602542(CHEMBL4594870)
Affinity DataIC50: 0.278nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50602544(CHEMBL4594757)
Affinity DataIC50: 0.416nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM509972(Advanced SARS-CoV-2 Inhibitor 6e | acs.jmedchem.1c...)
Affinity DataIC50: 0.5nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM509973(Advanced SARS-CoV-2 Inhibitor 6j | acs.jmedchem.1c...)
Affinity DataIC50: 0.5nMAssay Description:FRET-based enzymatic assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50201701(cis-4-(2,3-dimethylphenoxy)-6-oxa-1-aza-bicyclo[3....)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM16510(HO-tES-Leu-NH-CH2-CH2CH(CH3)2 | (2S,3S)-3-[[(2S)-4...)
Affinity DataIC50: 1.53nMpH: 6.8 T: 2°CAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2009
Entry Details
PCBioAssay
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50107639(3-{2-[2-(4-Chloro-2-fluoro-benzoylamino)-3-m-tolyl...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50201705((1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]oc...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM16509(CA074 | CHEMBL490920 | (2S)-1-[(2S,3S)-3-methyl-2-...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of cathepsin B (unknown origin) assessed as reduction in 7-amino-4-methylcoumarin formation using Z-Arg-Arg-MCA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM16508((2S)-1-[(2S,3S)-2-{[(2S,3S)-3-(ethoxycarbonyl)oxir...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of cathepsin B (unknown origin) assessed as reduction in 7-amino-4-methylcoumarin formation using Z-Arg-Arg-MCA as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50163831((2S)-1-cyclohexylpropan-2-yl 1-cyanoazetidine-2-ca...)
Affinity DataIC50: 2.40nMAssay Description:Inhibitory concentration against human cathepsin B using 10 uM Cbz-Phe-Arg-AMCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM16509(CA074 | CHEMBL490920 | (2S)-1-[(2S,3S)-3-methyl-2-...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of cathepsin B in human SH-SY5Y cells using RR-AMC as substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50250153(3-acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-ni...)
Affinity DataIC50: 3.11nMAssay Description:Inhibition of human liver cathepsin B after 30 mins by fluorometric end-point assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM16509(CA074 | CHEMBL490920 | (2S)-1-[(2S,3S)-3-methyl-2-...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of cathepsin B (unknown origin) using RR-AMC as substrate preincubated for 30 mins followed by substrate addition and further incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50135541(5-{(R)-2-Cyano-2-[(S)-2-(3-oxo-1,3-dihydro-isobenz...)
Affinity DataIC50: 4.10nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM16509(CA074 | CHEMBL490920 | (2S)-1-[(2S,3S)-3-methyl-2-...)
Affinity DataIC50: 4.40nMpH: 5.5 T: 2°CAssay Description:Inhibition of cathepsin B was assayed in reaction buffer (50 mM NaOAc-HCl, 2 mM dithiothreitol, 2 mM EDTA, pH 5.5) containing 20 µM substrate an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2014
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of cathepsin B (unknown origin) using Cbz-Phe-Arg-AMC as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50135543(3-{(R)-2-Cyano-2-[(S)-2-(2-methyl-1,3-dioxo-2,3-di...)
Affinity DataIC50: 4.90nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50135533((S)-N-[(R)-Cyano-(3-tetrazol-1-yl-benzyloxymethyl)...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50201700((1R,2S)-2-phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octan-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50135537(3-{(R)-2-Cyano-2-[(S)-2-(3-oxo-indan-5-ylamino)-3-...)
Affinity DataIC50: 5.30nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50135535(3-{(R)-2-Cyano-2-[(S)-2-(1,1-dimethyl-3-oxo-1,3-di...)
Affinity DataIC50: 5.30nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50107646(3-[4-Cyano-4-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50: 5.60nMAssay Description:Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50229129(4-methyl-N-((S)-1-oxo-3-phenyl-1-((S)-5-phenyl-1-(...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human Cathepsin B using Cbz-Phe-Arg-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50135546(3-{(R)-2-Cyano-2-[(S)-2-(3-oxo-1,3-dihydro-isobenz...)
Affinity DataIC50: 6.5nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataIC50: 6.80nMAssay Description:Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate measured at 20 mins by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCathepsin B(Rat)
Stanford University

LigandPNGBDBM36331(Ac-YFR-AMOK 10b)
Affinity DataIC50: 7.30nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50033762(Gallinamide A)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50201699((1R,2S)-2-isobutoxy-7-oxa-5-aza-bicyclo[3.2.1]octa...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50135532(3-{2-cyano-2-[1-(3-methyloxycarbonylanilino)-2-(3-...)
Affinity DataIC50: 8.60nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50135544(2-Chloro-5-[(R)-2-cyano-2-((S)-2-phenylamino-3-m-t...)
Affinity DataIC50: 8.70nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50331787((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human Cat B in HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50331787((S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl...)
Affinity DataIC50: 9nMAssay Description:Reversible inhibition of human cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50549374(CHEMBL4746374)
Affinity DataIC50: 9nMAssay Description:Inhibition of human cathepsin B at pH 6 using Z-Phe-Arg-AMC fluorogenic peptide as substrate preincubated for 2 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50135547(3-{(R)-2-Cyano-2-[(S)-2-(2-methyl-3-oxo-2,3-dihydr...)
Affinity DataIC50: 9.30nMAssay Description:Inhibitory activity against cathepsin B (catB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50107620(3-[2-(2-Benzoylamino-3-m-tolyl-propionylamino)-2-c...)
Affinity DataIC50: 9.40nMAssay Description:Inhibitory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50286441(Ac-LLR-CHO | Ac-Leu-Leu-Arg-H | (S)-2-((S)-2-Acety...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant cathepsin B after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50107620(3-[2-(2-Benzoylamino-3-m-tolyl-propionylamino)-2-c...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
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