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Report error Found 602 Enz. Inhib. hit(s) with Target = 'Carboxypeptidase B'
TargetCarboxypeptidase B2(Rat)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50575770(CHEMBL4858095)
Affinity DataEC50:  378nMAssay Description:Inhibition of TAFI in Sprague-Dawley rat blood TAFI incubated for 2 mins using hippuryl-arginine as substrate by thromboelastometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Rat)
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50575780(CHEMBL4878039)
Affinity DataEC50:  389nMAssay Description:Inhibition of TAFI in Sprague-Dawley rat blood TAFI incubated for 2 mins using hippuryl-arginine as substrate by thromboelastometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395732(CHEMBL2164462)
Affinity DataIC50: 0.00200nMAssay Description:Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395730(CHEMBL2164450)
Affinity DataIC50: 0.0250nMAssay Description:Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B(Pig)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395732(CHEMBL2164462)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50144342(3-((1R,3S)-3-Amino-cyclopentyl)-2-[1-(3,3-dimethyl...)
Affinity DataIC50: 1nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144333(3-(6-Amino-5-methyl-pyridin-3-yl)-2-[1-(4-methyl-p...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144336(3-(6-Amino-5-methyl-pyridin-3-yl)-2-[1-(3-methyl-b...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144342(3-((1R,3S)-3-Amino-cyclopentyl)-2-[1-(3,3-dimethyl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089691(CHEMBL3577425)
Affinity DataIC50: 1nMAssay Description:Inhibition of CBP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50089758(CHEMBL3577442)
Affinity DataIC50: 1nMAssay Description:Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50575776(CHEMBL4868605)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human activated TAFI incubated for 45 mins using hippuryl-arginine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395735(CHEMBL2164459)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B(Pig)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395735(CHEMBL2164459)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B(Pig)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395737(CHEMBL2164457)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50089687(Anabaenopeptin F)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50089688(ANABAENOPEPTIN B)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50275212(CHEMBL4127473)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human plasma activated thrombin-activatable fibrinolysis inhibitor after 10 mins in presence of DTTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2020
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50089686(CHEMBL3577334)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50144337(3-(6-Amino-pyridin-3-yl)-2-[1-(4-methyl-pentyl)-1H...)
Affinity DataIC50: 2nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395737(CHEMBL2164457)
Affinity DataIC50: 2nMAssay Description:Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50575768(CHEMBL4846664)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human activated TAFI incubated for 45 mins using hippuryl-arginine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109264(US8609710, 40)
Affinity DataIC50: 2.60nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
Go to US Patent

TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)
Affinity DataIC50: 2.70nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM120796(US8710232, 33)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI activity kit from American Diagnostica (Pr. No. 874). This ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2014
Entry Details
Go to US Patent

TargetCarboxypeptidase B(Pig)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50201429(2-(1-carbamimidoylpiperidin-3-yl)-3-mercaptopropan...)
Affinity DataIC50: 3nMAssay Description:Inhibition of porcine pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50089691(CHEMBL3577425)
Affinity DataIC50: 3nMAssay Description:Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetCarboxypeptidase B(Pig)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50201429(2-(1-carbamimidoylpiperidin-3-yl)-3-mercaptopropan...)
Affinity DataIC50: 3nMAssay Description:Inhibition of porcine pancreatic carboxypeptidase BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50197573(CHEMBL3912764)
Affinity DataIC50: 3nMAssay Description:Inhibition of activated human plasma TAFI incubated for 15 mins by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2018
Entry Details Article
PubMed
TargetCarboxypeptidase B(Pig)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395734(CHEMBL2164460)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B(Pig)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395733(CHEMBL2164461)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50144337(3-(6-Amino-pyridin-3-yl)-2-[1-(4-methyl-pentyl)-1H...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human carboxypeptidase B (CPB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50089751(CHEMBL3577435)
Affinity DataIC50: 4nMAssay Description:Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50089755(CHEMBL3577439)
Affinity DataIC50: 4nMAssay Description:Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50089756(CHEMBL3577440)
Affinity DataIC50: 4nMAssay Description:Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395734(CHEMBL2164460)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM326336(US9662310, Example 1 | US9662310, Example 28 | (1R...)
Affinity DataIC50: 4.5nMAssay Description:HEPES buffered saline (20 mM HEPES, 150 mM NaCl, pH 7.4; hereinafter, referred to as HBS) was used in the preparation of a reaction solution. To 12 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2019
Entry Details
Go to US Patent

TargetCarboxypeptidase B(Pig)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395728(CHEMBL2164463)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50135934(3-(6-Amino-pyridin-3-yl)-2-[1-(3-methyl-butyl)-1H-...)
Affinity DataIC50: 5nMAssay Description:Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50201427(2-(3-guanidinophenyl)-3-mercaptopropanoic acid | C...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human activated thrombin activatable fibrinolysis inhibitorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50575770(CHEMBL4858095)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human activated TAFI incubated for 45 mins using hippuryl-arginine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50575775(CHEMBL4861532)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human activated TAFI incubated for 45 mins using hippuryl-arginine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109265(US8609710, 35 (2S,4R form))
Affinity DataIC50: 5.10nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
Go to US Patent

TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395733(CHEMBL2164461)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109258(US8609710, 34 (2S,4S form))
Affinity DataIC50: 5.40nMAssay Description:Enzyme inhibition assay using TAFIa.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2014
Entry Details
Go to US Patent

TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50395728(CHEMBL2164463)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50135936(3-(6-Amino-pyridin-3-yl)-2-(1-butyl-1H-imidazol-4-...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibition of purified Carboxypeptidase B (CPB) by clot lysis assay in human plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM173886(US9688645, 1-1)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:The prepared substances were tested for TAFIa inhibition using the Actichrome plasma TAFI Activity Kit from American Diagnostica (Pr. No. 874). This ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetCarboxypeptidase B2(Human)
Showa Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50575780(CHEMBL4878039)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human activated TAFI incubated for 45 mins using hippuryl-arginine as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
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