Compile Data Set for Download or QSAR
Report error Found 390 Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 [44-168]'
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205429( (R)-JQ1 (3) | US9320741, (R)-JQ1 | US10407441, Co...)
Affinity DataKd:  14nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205430((6S+2S)-PEG0 (6))
Affinity DataKd:  0.0340nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKd:  0.0100nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205432((6S+2S)-PEG2 (8))
Affinity DataKd:  0.0140nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205433((6S+2S)-PEG3 (9))
Affinity DataKd:  0.0290nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205434((6S+2S)-PEG4 (10))
Affinity DataKd:  0.0230nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205435((6S+2S)-PEG7 (11))
Affinity DataKd:  0.0260nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205438(6S+IBET-PEG2 (19))
Affinity DataKd:  0.0620nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataKd:  39.5nMpH: 7.4Assay Description:ITC experiments were carried out on anAuto-ITC200 titration microcalorimeter (Malvern Instruments). All experimentswere carried out at 25 °C while st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKd:  16.7nMpH: 7.4Assay Description:ITC experiments were carried out on anAuto-ITC200 titration microcalorimeter (Malvern Instruments). All experimentswere carried out at 25 °C while st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205453(MTI (35))
Affinity DataKd:  3.09nMpH: 7.5 T: 2°CAssay Description:Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM50260101(CHEMBL4068487 | US10689390, Compound 38 | US113193...)
Affinity DataIC50: 0.5nMAssay Description:Compounds were diluted by step-down dilution method (final concentration of DMSO was 1%) and added to the wells of a 384 well opti plate at desired c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM684552(US12030880, Example 18)
Affinity DataIC50: 0.640nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD1) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataIC50: 0.758nMpH: 7.5 T: 2°CAssay Description:Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205435((6S+2S)-PEG7 (11))
Affinity DataIC50: 0.789nMpH: 7.5 T: 2°CAssay Description:Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM684529(US12030880, Example 4)
Affinity DataIC50: 0.930nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD1) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209487(US9266891, III-28 | US10328074, Example III-28 | U...)
Affinity DataIC50: 1nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM209487(US9266891, III-28 | US10328074, Example III-28 | U...)
Affinity DataIC50: 1nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM448073(US10689390, Compound 23 | US11319326, Compound 23)
Affinity DataIC50: 1nMAssay Description:Compounds were diluted by step-down dilution method (final concentration of DMSO was 1%) and added to the wells of a 384 well opti plate at desired c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205456((2S+2S)-PEG1 (5))
Affinity DataIC50: 1.17nMpH: 7.5 T: 2°CAssay Description:Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205432((6S+2S)-PEG2 (8))
Affinity DataIC50: 1.28nMpH: 7.5 T: 2°CAssay Description:Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM684521(US12030880, Example 2)
Affinity DataIC50: 1.40nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD1) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM448074(US10689390, Compound 25 | US11319326, Compound 25)
Affinity DataIC50: 1.60nMAssay Description:Compounds were diluted by step-down dilution method (final concentration of DMSO was 1%) and added to the wells of a 384 well opti plate at desired c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM50260078(CHEMBL4095826 | US10689390, Compound 26 | US113193...)
Affinity DataIC50: 2nMAssay Description:Compounds were diluted by step-down dilution method (final concentration of DMSO was 1%) and added to the wells of a 384 well opti plate at desired c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205433((6S+2S)-PEG3 (9))
Affinity DataIC50: 2.25nMpH: 7.5 T: 2°CAssay Description:Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM684543(US12030880, Example 8)
Affinity DataIC50: 2.40nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD1) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205434((6S+2S)-PEG4 (10))
Affinity DataIC50: 2.95nMpH: 7.5 T: 2°CAssay Description:Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209474(US9266891, III-15 | US10328074, Example III-15 | U...)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209481(US9266891, III-22 | US10328074, Example III-22 | U...)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209482(US9266891, III-23 | US10328074, Example III-23 | U...)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM242688(US9422290, I-1)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM242696(US9422290, II-3)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM242702(US9422290, II-9)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM242713(US9422290, III-2)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM242714(US9422290, III-3)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM209474(US9266891, III-15 | US10328074, Example III-15 | U...)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM209481(US9266891, III-22 | US10328074, Example III-22 | U...)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM209482(US9266891, III-23 | US10328074, Example III-23 | U...)
Affinity DataIC50: 3nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM50260080(CHEMBL4088097 | US10689390, Compound 14 | US113193...)
Affinity DataIC50: 3nMAssay Description:Compounds were diluted by step-down dilution method (final concentration of DMSO was 1%) and added to the wells of a 384 well opti plate at desired c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM684544(US12030880, Example 9)
Affinity DataIC50: 3nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD1) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205430((6S+2S)-PEG0 (6))
Affinity DataIC50: 3.58nMpH: 7.5 T: 2°CAssay Description:Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209457(US9266891, II-1 | US10328074, Example II-1 | US110...)
Affinity DataIC50: 4nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168]/Histone H4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM209508(US9266891, III-49 | US10328074, Example III-49 | U...)
Affinity DataIC50: 4nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 uM start concentration) in white OptiPlate-384 (PerkinElme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM242701(US9422290, II-8)
Affinity DataIC50: 4nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM209457(US9266891, II-1 | US10328074, Example II-1 | US110...)
Affinity DataIC50: 4nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM209508(US9266891, III-49 | US10328074, Example III-49 | U...)
Affinity DataIC50: 4nMAssay Description:Compounds are diluted in serial dilution 1:5 in assay buffer from 10 mM stock in DMSO (100 μM start concentration) in white OptiPlate-384 (Perki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM448081(US10689390, Compound 37 | US11319326, Compound 37)
Affinity DataIC50: 4nMAssay Description:Compounds were diluted by step-down dilution method (final concentration of DMSO was 1%) and added to the wells of a 384 well opti plate at desired c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM448083(US10689390, Compound 39 | US11319326, Compound 39)
Affinity DataIC50: 4nMAssay Description:Compounds were diluted by step-down dilution method (final concentration of DMSO was 1%) and added to the wells of a 384 well opti plate at desired c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM684547(US12030880, Example 12)
Affinity DataIC50: 4.10nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD1) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM448076(US10689390, Compound 27 | US11319326, Compound 27)
Affinity DataIC50: 4.40nMAssay Description:Compounds were diluted by step-down dilution method (final concentration of DMSO was 1%) and added to the wells of a 384 well opti plate at desired c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

Displayed 1 to 50 (of 390 total ) | Next | Last >>
Jump to: