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Report error Found 17 Enz. Inhib. hit(s) with Target = 'Aquaporin-1'
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50607943(CHEMBL1740905)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of AQP1 water channel in human erythrocyte by stopped-flow spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM94509((E)-but-2-enedioic acid;2-[4-tert-butyl-1-[(4-fluo...)
Affinity DataEC50:  4.80E+4nMAssay Description:Inhibition of AQP1 water channel in human erythrocyte by stopped-flow spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50607941(CHEMBL5268096)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonist activity at human AQP1 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swellingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50089038(CGP 71683 | CHEMBL17645 | Naphthalene-1-sulfonic a...)
Affinity DataIC50: 2.70E+3nMAssay Description:Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50166561(Naphthalene-1-sulfonic acid {4-[(4-amino-quinazoli...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50354083(CHEMBL1836102 | N-{[(1r,4r)-4-{[(4-aminoquinazolin...)
Affinity DataIC50: 3.90E+3nMAssay Description:Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50607942(CHEMBL5280011)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM178091(5-chloro-N-{[(1r,4r)-4-{[(4-aminoquinazolin-2-yl)a...)
Affinity DataIC50: 5.80E+3nMAssay Description:Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM178092({[7-(2,4-dichlorophenyl)-5-fluoro-2,3-dihydro-1-be...)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM178092({[7-(2,4-dichlorophenyl)-5-fluoro-2,3-dihydro-1-be...)
Affinity DataIC50: 9.80E+3nMAssay Description:Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM178093([7-(2,4-dichlorophenyl)-5-fluoro-2,3-dihydro-1-ben...)
Affinity DataIC50: 1.52E+4nMAssay Description:Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM178093([7-(2,4-dichlorophenyl)-5-fluoro-2,3-dihydro-1-ben...)
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50607939(CHEMBL1537920)
Affinity DataIC50: 1.75E+4nMAssay Description:Inhibition of human AQP1 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50607938(CHEMBL5280895)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human AQP1 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM178094({[7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-be...)
Affinity DataIC50: 2.94E+4nMAssay Description:Osmotic water permeability was measured at 22-24 °C bymonitoring 90° scattered light intensity at 520 nm wavelength. Measurements were made using a P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2016
Entry Details Article
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM178094({[7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-be...)
Affinity DataIC50: 2.94E+4nMAssay Description:Inhibition of human AQP1 water channel expressed in CHO cells incubated for 10 mins by FLIPR Tetra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAquaporin-1(Human)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50607940(CHEMBL5282904)
Affinity DataIC50: 1.70E+7nMAssay Description:Inhibition of human AQP1 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed